Mestinon for Long Covid

I am taking Mestinon. After 3+ years of suffering with shortness of breath, dizziness, Post Exertional Malaise, etc, I was diagnosed with POTS. The diagnosis was made as a result of a tilt table test. I take 1/2 tablet of Pyridostigmine (generic Mestinon) twice a day. My neurologist says that I will be taking it for the rest of my life. I have very few side effects. I got my life back and am now walking vigorously, playing golf, participating in aerobic dancing, etc. Once in awhile, after an especially busy day, I feel the need to take a break - get short of breath, dizzy, etc. My doctor says I still need to listen to my body. I continue to suffer with migraine headaches, but not everyday, and GI problems are present. I have had migraines on and off since adolescence. I, too, researched the drug and understand that it helps with acetylcholine transmission between nerves. In any case, I call it my wonder drug. Before I met my neurologist and received a fresh look at my Long Covid, I had settled into thinking that I would always be a less active person than before Covid. Good luck and if you try Mestinon, let me know how it goes.

Thankyou so much for responding!That is wonderful that it is helping and you are finally feeling better.I am desperate at this point and trying to see if anything would help.My whole body was attacked and the muscle weakness is getting worse.I try to explain to the doctors that I have lost the strength in my diaphram/sternum area that normally pushes the belly down and they just don't understand.I also have heart issues along with my other physical symptoms.I notice that if I hear a loud noise or anything like that my heart goes crazy.Almost like it can't handle it.I never had an issue like that until this illness came on.I really believe it is the vagus nerve damage that was probably brought on from covid.I have tried tens machines,PT,chiropractor,acupuncturist,but nothing has helped.

Hi
Short answer: the Mestinon was a miracle for me. I started low last summer- 8 mo ago. I now take 60 am and 30 pm with no side effects.
I had a flare last month after a family crisis and added Nicotine patch 7 mg.

I am 18 mo with Long Covid. Like others I’ve tried PT, supplements, acupuncture , etc.

That is Amazing to hear!The Doctors still don't know what is wrong with me and I do think it is related to long covid.The neurologist did order new blood work for seronegative Myasthenia Diseases.My TSH was slightly high so they raised my synthroid level.They are also testing me for Cushings Disease.My whole body was atracked,but the specialists can only find little things.I have lost the strength in my pelvis area,shoulders,and trunk.I was just thinking mestinon would give me the strength to start exercising again.I went from an athlete to basically disabled.I did do a Genetic test that showed a possibility of MD Diseases such as limb girdle muscular dystrophy.We don't have MD on either side of my Family,but maybe covid triggered something.It is just frustrating the Doctors have no idea what is wrong with me.

It’s extremely frustrating. I contracted Covid on a trip to India, Aug 22. Prior to that I had been extremely active, I have my own medical practice, and typically walk/hike/ride horses 2 hrs a day, or more.
I was completely debilitated, unable to think, climb a few stairs, or even just standing for a short while was impossible.
I do believe there is hope.
Try the Mestinon !

I am taking Mestinon. After 3+ years of suffering with shortness of breath, dizziness, Post Exertional Malaise, etc, I was diagnosed with POTS. The diagnosis was made as a result of a tilt table test. I take 1/2 tablet of Pyridostigmine (generic Mestinon) twice a day. My neurologist says that I will be taking it for the rest of my life. I have very few side effects. I got my life back and am now walking vigorously, playing golf, participating in aerobic dancing, etc. Once in awhile, after an especially busy day, I feel the need to take a break - get short of breath, dizzy, etc. My doctor says I still need to listen to my body. I continue to suffer with migraine headaches, but not everyday, and GI problems are present. I have had migraines on and off since adolescence. I, too, researched the drug and understand that it helps with acetylcholine transmission between nerves. In any case, I call it my wonder drug. Before I met my neurologist and received a fresh look at my Long Covid, I had settled into thinking that I would always be a less active person than before Covid. Good luck and if you try Mestinon, let me know how it goes.

did mestinon reduce migraines at all?