Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.
Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.
A decade ago, Tom Hemming Karlsen, M.D., Ph.D., who leads the Norwegian PSC Research Center (NoPSC), joined forces with Konstantinos Lazaridis, M.D., of Mayo Clinic to uncover the culprits driving PSC. At the time, neither could have foreseen the transformative power of their collaborative genetic study on the global [...]
For the past 15 years, PSC Partners Seeking a Cure has sought to be a safe haven, providing information and support, for those diagnosed with PSC and their caregivers. The non-profit organization got its start thanks to the determination of one Denver-area woman, Ricky Safer, and [...]
Mayo Clinic is at the forefront of research designed to uncover the environment’s role in PSC, thanks to a unique collaboration with Gary Miller, PhD, a toxicologist and Professor of Environmental Health Sciences and Vice Dean, Research Strategy and Innovation, at Columbia University.
Dr. Miller’s interest in figuring [...]
This past year, our PSC team accomplished several important milestones that make us proud: We received an NIDDK award to study the pathogenesis and outcomes of PSC for the next five years, launched our PSC blog via Mayo Clinic Connect, and published several seminal papers to improve the knowledge [...]
Human environmental exposures and corresponding metabolic responses are highly variable, and may contribute to disease in genetically susceptible individuals. Recently, ultra-high resolution mass spectrometry (HRMS) has allowed precise detection of over 50,000 signals, revolutionizing the ability to measure biologic responses (metabolomics) to cumulative exposures such as environmental toxicants, diet, [...]