Primary Sclerosing Cholangitis (PSC)

Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.

Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.

PUBLIC PAGE
Feb 3, 2020

Genomic Profiling of Cholangiocarcinoma among PSC Patients

By Ethan McConkey, Moderator @ethanmcconkey
In a recent study, published in the journal Hepatology, Goeppert B. et al., reported genomic features of cholangiocarcinoma (i.e., bile duct cancer) in patients with primary sclerosing cholangitis (PSC). In this excellent international effort from 11 medical centers in eight countries, the authors carried out DNA sequencing of 42 [...]
Genomic Profiling of Cholangiocarcinoma among PSC Patients
Jan 20, 2020

Mayo Clinic launches Vancomycin clinical trial for Primary Sclerosing Cholangitis

By Konstantinos N. Lazaridis, M.D. @klazaridis
Mayo Clinic in Minnesota, Arizona and Florida is currently conducting a randomized placebo controlled clinical trial, examining the impact of oral vancomycin on markers of cholestasis among patients with PSC. The treatment period is approximately 18 months and requires about five clinic visits along with lab draws at home. [...]
Mayo Clinic launches Vancomycin clinical trial for Primary Sclerosing Cholangitis
Dec 30, 2019

Liver Stiffness is Associated with PSC Outcomes

By Konstantinos N. Lazaridis, M.D. @klazaridis
In a recent paper, published in the Journal Clinical Gastroenterology and Hepatology, Eaton et al., found that measuring liver stiffness of patients suffering from PSC is associated with outcomes of the disease. "Monitoring liver stiffness with magnetic resonance elastography has prognostic value. Both baseline liver stiffness and changes in [...]
Liver Stiffness is Associated with PSC Outcomes
Dec 16, 2019

Statin Use and PSC

By Konstantinos N. Lazaridis, M.D. @klazaridis
In a recent paper published in the journal Clinical Gastroenterology and Hepatology,  Stokkeland K. et al., reported the effects of exposure to medications on the outcomes of PSC using a population-based cohort of 2,914 patients from Sweden. The authors found that use of statins or azathioprine, among patients with [...]
Statin Use and PSC
Dec 2, 2019

Coping Needs of Children with Primary Sclerosing Cholangitis

By Konstantinos N. Lazaridis, M.D. @klazaridis
Primary Sclerosing Cholangitis (PSC) is a slowly progressing disease that affects both adults and children. Several of the clinical features of the disease are different between pediatric and adult patients. Importantly, the coping elements of the disease in children and their families are unique. In this presentation, Dr. Mounif [...]
Coping Needs of Children with Primary Sclerosing Cholangitis

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