Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.
Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.
Primary Sclerosing Cholangitis (PSC) often strikes without a patient noticing any symptoms or signs of disease. For Nicole Jockisch Carlos, an Atlanta resident, this was the case.
Bloodwork ordered by her doctor in advance of a fitness competition revealed elevated liver enzymes. Although Carlos shared with her doctor [...]
When Dr. Nicholas LaRusso arrived at Mayo Clinic for a three-month elective during his fourth year of medical school, he knew where he wanted to be.
“Mayo Clinic was like the Emerald City. While I loved my training in New York where I worked at one of the [...]
In an effort to better predict the outcomes for Primary Sclerosing Cholangitis (PSC) patients, Mayo Clinic researchers have created a new tool called the Primary Sclerosing Cholangitis Risk Estimate Tool or PREsTo.
The prediction tool was developed and validated through the use of machine learning, a type of [...]
A Mayo Clinic-led research consortium recently received a significant, five-year grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to study the pathogenesis and outcomes of Primary Sclerosing Cholangitis (PSC), a chronic, progressive liver disease that lacks effective medical therapy. Dr. Konstantinos Lazaridis, a hepatologist [...]
Having trained at the National Human Genome Research Institute (NHGRI) in the early 2000s, Konstantinos N. Lazaridis, M.D., is no stranger to sifting through sequences of human genomes to uncover genetic variants and mutations associated with diseases such as Primary Sclerosing Cholangitis (PSC).
“But to sift for the [...]