Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.
Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.
Primary Sclerosing Cholangitis (PSC) is a slowly progressing disease that affects both adults and children. Several of the clinical features of the disease are different between pediatric and adult patients. Importantly, the coping elements of the disease in children and their families are unique.
In this presentation, Dr. Mounif [...]
Primary Sclerosing Cholangitis (PSC) is a rare, chronic liver disease that affects about 1 in 10,000 people.
In this presentation, Robert C. Huebert, M.D, an Associate Professor of Medicine and transplant Hepatologist from Mayo Clinic, provides a great overview of PSC, including promising approaches of regenerative medicine to [...]
Meaningful and reliable predictors of disease progression in PSC are currently lacking despite efforts over the past three decades. Patients with PSC often demonstrate increased plasma bile acids (BA) concentrations due to ongoing cholestasis, a hallmark of the disease. However, the relationship between composition of the BA in blood [...]
Aging (senescent) bile duct cells , i.e., cholangiocytes, demonstrate an arrest of the cell cycle, hypersecretion of inflammatory molecules and resistance to cell death. O’Hara et al., previously reported that aging of cholangiocytes is a feature in PSC patients, and that this event is regulated by a central molecular [...]
About 50 percent of patients with Primary Sclerosing Cholagnitis (PSC) have no symptoms. Yet, patients with PSC have abnormal laboratory tests, which fluctuate over time and even normalize at times. Understanding the meaning and significance of liver testing and other procedures in PSC is important for the empowered patient. [...]