Your experience with Orgovyx

Posted by rps55481 @rps55481, May 17 4:12pm

Good evening, Recently diagnosed with localized stage 1 gleason 8 prostate cancer. My treatment plan is ADT, SBRT, then HDR. Started Orgovyx on May 15, 2026. So far just a slight headache. I am a 67 year old active person. Pickleball 2-3 times per week, weight training 2-3 per week, get in my 10-14k steps per day, e-bike 30 miles per week, and yoga once a week. Now focusing on 100-120g of protein per day. Hoping this level of activity will mitigate some of the side effects. Would like feedback with those that have been on Orgovyx. Has increase activity maintained or increased muscle mass, and energy level? Any dietary/meal planning suggestions would be greatly appreciated. Thank you in advance.

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Got off Orgovyx 2.5 months ago after 14 months on it. No question that exercise helps but by the end I had no interest in much. After getting off, my libido has returned. I am able to orgasm, mainly dry. I’m 74.

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Profile picture for surftohealth88 @surftohealth88

@jim18

Thanks Jim very much for detailed instructions 👍, I will make sure that my husband follows your protocol since it obviously worked 😃 ! Good for you !

Did you start using those supplements as soon as you started Orgovyx ?

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@surftohealth88 Yes, within a few days. Remember that the exercise regimen is more important than the supplements, but I believe you have that down.
FYI: I worked every day while on ADT and getting radiation treatments. I did my treatments early in the morning before work, others schedule late. Sometimes I had to take a call right after (brought laptop for that) but was usually able to block off enough time to get back. Never had to inform my management about treatment.

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Profile picture for jim18 @jim18

@surftohealth88 Yes, within a few days. Remember that the exercise regimen is more important than the supplements, but I believe you have that down.
FYI: I worked every day while on ADT and getting radiation treatments. I did my treatments early in the morning before work, others schedule late. Sometimes I had to take a call right after (brought laptop for that) but was usually able to block off enough time to get back. Never had to inform my management about treatment.

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@jim18
I am soooooo grateful for your input about all aspects of ADT 🤩 .
I feel much more confident now that many SAs can be mitigated with proper nutrition, exercise and supplementation. It is so comforting to know that you were able to work 👍 with zero problems. My husband is early morning person too, so he will try to get morning appointments for RT. He plans to keep his salvage treatment private because long time ago he was naive and made mistake by sharing his medical issue with management which backfired very soon after - he got "downsizing package" out of the blue even though he got stellar performance review just 2 months before that.
THANK YOU 💗

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Profile picture for surftohealth88 @surftohealth88

@jim18
I am soooooo grateful for your input about all aspects of ADT 🤩 .
I feel much more confident now that many SAs can be mitigated with proper nutrition, exercise and supplementation. It is so comforting to know that you were able to work 👍 with zero problems. My husband is early morning person too, so he will try to get morning appointments for RT. He plans to keep his salvage treatment private because long time ago he was naive and made mistake by sharing his medical issue with management which backfired very soon after - he got "downsizing package" out of the blue even though he got stellar performance review just 2 months before that.
THANK YOU 💗

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@surftohealth88 Look at this from management's view. If you have to reduce staff it is unlikely that your superiors will approve replacements if anyone quits. Therefore, older workers (may retire) and anyone with medical issues get special consideration in addition to the poor performers. Better to put them on the list vs. taking the risk of being down additional staff. That is why nothing should be mentioned to an employer unless a long leave of absence is required. Nothing good will come from it and as you note some real negative actions may occur. HIPPA typically isolates what happens with health insurance and the treatment may be over by the time the claims hit.

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Profile picture for mjp0512 @mjp0512

My experience - Began taking Orgovyx 6/7/2025. First 2 months PSA dropped from 30 to 0.19. Hot flashes, joint pain were pretty common. Muscle weakness began about the 4th month, along with mild weight gain. (yes, I walk and do resistance training). I also now have a pair of boobs that some old girlfriends would be envious of. One plus is I don't have to deal with body hair anymore; it's gone. PSA began rising in December 2025 and is now in double digits again.

Short version - If I had known it was only going to work for six months, I would not have put my body through that. That said, I know I am an exception to the norm; Or as my oncologist said, "You're very weird." May your results be better.

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@mjp0512 I’m curious. Why did your doc not combine Orgovyx with Nubeqa which I’m told is the standard nowadays?

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@lsk1000 - He did. Been taking both since June 2025. Supposed to increase time to castrate resistance. It didn't. Like my GUO said, "You're very weird." Revised treatment plan coming next month after I get L5 zapped, so we'll see what happens then.

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