What is your copay for HRT Combipatch .05/.25 ?

Posted by seapen @seapen, Nov 4, 2025

I just started HRT using the Combipatch .05/.25. I was very surprised that it costs $135/month. I have good insurance that I pay a fortune for, so I am not used to having to pay so much. I am wondering if it can be purchased at a discount some how. I live near the Canadian border and I would love to take a trip to Quebec!

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Profile picture for maryandnana @maryandnans

@seapen thanks I just don't understand how where you live affects the cost. I live in Missouri

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@maryandnans
It might be less expensive in Canada
I live near the border

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Profile picture for mayblin @mayblin

CombiPatch doesn’t have a generic version currently. That may explain your high copay, especially if it’s on a non-preferred formulary tier.

The estrogen (estradiol) in CombiPatch is bioidentical, but the progestin part (norethindrone acetate) is synthetic. You can get the same estrogen from a much cheaper generic estradiol patch, and pair it with micronized progesterone (generic for Prometrium) which is bioidentical.

It’s worth discussing with your prescribing physician to see if switching is appropriate for you. My obgyn prescribed Vivelle-Dot (patch) and Prometrium (oral pill) - both have generics, and my 3mo supply costs $20 each (with commercial insurance). A nice bonus: Prometrium often helps with sleep when taken at bedtime.

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@mayblin Those generic prices sound. Are you in the U.S?

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