What is minimum period of Alendronate to minimise Prolia rebound?

Posted by surefire @surefire, Jan 14, 2024

I started on Prolia in July 2022 on advice from my doctor that the treatment would be for only 4-5 years and thereafter I could stop. I have taken 3 Prolia injections, the last one in July 2023.

Before my 4th injection in Jan 2024, I started doing a lot of reading and decided that I do not want to be on any osteoporosis drug at all. So, instead of taking my 4th Prolia injection and to minimise the rebound effect from stopping Prolia, I started on a weekly dose of Alendronate.

However, I am really not comfortable taking Alendronate as well and would like to seek any advice/opinion on whether I am stuck with taking Alendronate for the next 6, 12 or even 24 months.

What is the shortest period I can be on Alendronate? Or should I just risk the rebound effect and stop my Alendronate now (I have taken 3 weekly doses so far)?

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Profile picture for dcwit @dcwit

That’s very disappointing, I will see my doc in May and have another scan… hoping I see improvement. I’m a bit nervous of trying a different prescription after reading some of the entries. Let me know what you go on and how you’re doing. Do you exercise?

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It is very disappointing
I do exercise. I just started a strong bones class through the university extension. It’s been twice a week. I do walk some, but not as good in the winter. Currently we are having an ice storm and the power went out. I also do some farm work daily that adds steps and lifting.

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Sounds like you are doing the best you can with ‘winter’ exercises. I live in Michigan so winters are indeed miserable for getting out to exercise. I walk on the treadmill for 45” every morning, do weights for my arms and some leg lifts. Needless to say, I’m not one to say I enjoy doing the exercises, but I grin and do it anyway. I also drink 2 glasses of milk each day and take vitamin D3 because that’s what my doctor recommended I do. I dread tomorrow as it is Monday and that’s when I take my weekly Fosamax…oh well. I hope your ice storm is over and you get your power back soon! Blessings

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Profile picture for patwerthman @patwerthman

I have had that also. I’m hoping to get a different doctor and a new prescription, as 3 years and my T score hasn’t changed

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It's possible that no change doesn't mean no improvement. If your T score was increasing and it's stopped, that's a good thing, no? Not saying you shouldn't explore other therapies, but don't be discouraged.

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T-scores
2022. -3.7
2023. -3.5
2024. -3.7

Hip slight improvements
No breaks yet

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Profile picture for dcwit @dcwit

Sounds like you are doing the best you can with ‘winter’ exercises. I live in Michigan so winters are indeed miserable for getting out to exercise. I walk on the treadmill for 45” every morning, do weights for my arms and some leg lifts. Needless to say, I’m not one to say I enjoy doing the exercises, but I grin and do it anyway. I also drink 2 glasses of milk each day and take vitamin D3 because that’s what my doctor recommended I do. I dread tomorrow as it is Monday and that’s when I take my weekly Fosamax…oh well. I hope your ice storm is over and you get your power back soon! Blessings

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Power is back on!
Good self discipline on exercise. That’s great!

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Profile picture for dcwit @dcwit

Sounds like you are doing the best you can with ‘winter’ exercises. I live in Michigan so winters are indeed miserable for getting out to exercise. I walk on the treadmill for 45” every morning, do weights for my arms and some leg lifts. Needless to say, I’m not one to say I enjoy doing the exercises, but I grin and do it anyway. I also drink 2 glasses of milk each day and take vitamin D3 because that’s what my doctor recommended I do. I dread tomorrow as it is Monday and that’s when I take my weekly Fosamax…oh well. I hope your ice storm is over and you get your power back soon! Blessings

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Besides D3, I take K2-MK4. The K2 helps your body direct calcium to the bones. D3 and K2 work well together.

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