1. < Osteoporosis & Bone Health

What are the long-term positive/negatives of taking osteoporosis meds?

Posted by julie59 @julie59, 4 days ago

I just found out I do have Osteoporosis--I need to decide which route to take: medication or not. What are some of the options people have used for medications? There is a medication that my doctor suggested-an injection for 1 year (not sure the name of it). My concern is--what happens to your osteoporosis after 5-10 years after the 1 year injection?
Has anyone had Osteoporosis for more than 5 years and have used one of the medication suggested-has it helped with longevity?

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gently | @gently | 1 day ago
In reply to @mayblin "I read your mind @gently :) Charts from manufacturer and clinical studies show continued bmd increases..." + (show)
@mayblin

I read your mind @gently 🙂

Charts from manufacturer and clinical studies show continued bmd increases over 12mo treatment period with Evenity, although the rate of increase declines gradually from beginning months towards the end of 12mo. Could this simply be explained by the strong upswing of P1NP (osteoblasts activity) during very early stages (~2wks post first dosing being strongest)? The pattern of bone marker changes with evenity resembles a pure anabolic, guess what, teriparatide when used with a higher dose once weekly formulated in Japan. This makes us wonder if a short burst of P1NP means a long lasting effects of osteoblasts then to the eventual mineralization, which shows up in dexa scan. Might these prolonged sequential events explain bmd increase throughout 12mo? The dual effects of evenity undoubtedly augment its bone building capability.

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Mayblin,
the bone marker changes in figure 1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7098919/#:~:text=Preclinical%20studies%20confirmed%20this%20idea,by%202019%2D12%2D12 evidence the decoupling typical of bone that is "thrown" rather than "built." ( I'm avoiding the term "anabolic" which no longer differentiates between bone built by osteoblasts coupled by osteoclasts.) Are you looking at rise and fall of bone markers or relationship between.
Thanks

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