Wegovy and nausea

@lisalucier
The short answer to the question is yes both nausea and stomachace with the 2.4 dosage.

I started per my Mayo PCP with lowest dose of Wegovy I think was .25 but those levels did not reduct my appetite. From .25 to before starting 2.4 I had very limited stomach upset. It was more bowel movement slow down that I noticed. I did not feel nausea. I did get a slight reduction at dinner in eating feeling a little full but only at that meal.

My wife got sick and I did not start the 2.4 level dose right away. When I did within 2 hours (was prior to bedtime) I could feel nausea and stomach discomfort.

When I woke up the next morning was quite frankly severe. I was really nauseated and had stomach pain. I vomited. I struggled and sent a message to my PCP about my symptoms. At lunch time I vomited again. I was given an acute visit to Mayo.

The doctor who saw me said no way to counter the drug it has to take is time to go through system and would take about 4-5 weeks to completely leave. I was told to eat very light and clear food. My doctor said I would normally prescribed a nausea pill for you but it would interfere with other medication you take.

Now what did I do to manage it. I tried eating mashed potatoes and let them dissolve in my mouth. This light and easy digetible food did not upset my stomach and I was able to keep it down. I chew a long time and ate very slow. I need to have protein but was not going to eat any meat. So I bought protein shakes. They were tasty and did not have an issue with them.

I drank gingerale. It seemed to quell stomach. I constantly felt nausea and was burping. I stayed with the mashed potatoes and protein drinks and did not vomit again. I watch not to lay down to soon after eating as would seem cause more nausea.

I don't want to put a negative on these medications. For some they have great success with them and minor side affects. For me none of the lower doses were working to reduce appetite and the highest one I got a severe reaction.

I wish it would have worked for me but I and others need to know once you stop them your appetite and stomach will eventually return to the way it was before. So you have to try to change you lifestyle and eating habits and not just count on being on a medication like Wegovy.

My PCP wanted me to consider Expound (spell?). He said it contained 2 recptors to lower appetite not just the one in Wegovy. But I have read on MCC others having issues with Expound as well. I was told we he would not even consider it for at least three months after I had the reaction to Wegovy.

Mounjaro is what i am taking and no nausea or stomach aches.I had some about 2 months after i started taking it.

I'd like to tag a few other Mayo Clinic Connect members who've talked about semaglutide (Wegovy) to see if they have had nausea and stomachache and if so, how to manage it @brianberchtold @jc76 @ami83 @isadora2021 @celia16. @predictable @neenagator64 @larry68 and @shiver may also have some input.

@wlb2, how have you felt in the last couple of days?

Oh, yeah. Missed one. Try not to drink at meals -- see if you can give it 30 min before and after eating. Drinking with food can be triggering. This is a significant behavioral change for some of us, and you need to be really careful not to dehydrate, especially if you also need to shift to multiple protein-rich snacks rather than eating three larger meals. In my case, I delay my first meal of the day and drink lots of fluids during that time, among other hacks.

I've had bariatric surgery, which led to severe nausea (called "dumping" if you decide to do a search for it); started tirzepatide last summer to get rid of the weight I had gained (to improve my knee arthritis), which led to a slew of GI side effects; and moved to semaglutide this year, largely to deal with the side effects.

One of the key reasons the weight went back on was that I eventually fell back on comfort food to assuage the dumping syndrome, so yeah, part of this is behavioral. However, I also devoted a lot of attention to figuring out my list of trigger foods, and that's what worked in the end.

This was a very useful experience when I started the GLP-1 RAs. I titrated up more slowly than they recommend, paused and stuck at a lower dosage than the maximum, and titrated down slowly. During this experience, I did make use of the controlled nausea as a tool to help manage my eating, but I also did a lot of tracking to figure out what made a difference, and also got a prescription for anti-nausea medication that I used sparingly. I found that the symptoms were worse with some foods than others, if I didn't stop eating immediately when I started to feel the first edge of nausea, and at meals later in the day (I used the medication to help me be able to go out to dinner for social occasions, since otherwise dinners were difficult for me). This may or may not be the same for you, but it's an example of sleuthing the issue out.

It's really important to prioritize protein and fiber when we eat so much less. Unfortunately, this has meant that I haven't been able to rely on plant proteins, where the protein requires eating more volume. In my case, vegetables are more triggering than fruit, especially cruciferous vegetables, so I'm skewing toward fruit.

My GI symptoms are only partially dose-related, meaning that dropping down to a lower dose helped a little but not a lot. That's why I switched to another drug in the family, which helped (as did the fact that I could get it as a multi-pen, which let me fine-tune dosages). Switching definitely helped, although it took a couple of months for my system to calm down.

This was not the only side effect I had, and I've systematically been going after each one. I don't think this is normal -- someone has to be a statistical outlier, and I guess I was elected -- and it really is normal for the nausea to be dose-dependent and to go away over time. But it does appear that the weight loss is not just a reaction to the nausea, and does not depend on that symptom. So if you can get the nausea under control, you may well see the weight loss still happen.

Welcome to Mayo Clinic Connect, @wlb2. Great to see you've connected with@roch and @jc76.

I personally took semaglutide (Wegovy) and really had the nausea you are mentioning at the two lowest doses. It was very much like morning sickness, and it would get so bad I'd have trouble focusing properly on my work. I ended up taking over-the-counter anti-nausea lozenges, which helped. Then my doctor prescribed prochlorperazine (Compazine), an anti-nausea medication. I know my doctor disliked prescribing one medication to deal with side effects from another, but taking it did help.

Overall, I had good weight loss with semaglutide, over 50 pounds down. However, I ultimately went off it and am taking another weight loss injection due to really severe side effects, especially as the dosage went up. I had basically chronic diarrhea, "death burps" that made my whole family roll down the windows in the car, intense abdominal cramping, and vomiting at random times so that my husband asked me to put "barf bags" in our cars. I even had some fecal incontinence one night at the highest dose when the semaglutide really did not seem to get along with what I ate and drank the evening before.

I look back at my time on semaglutide somewhat wistfully, due to the weight loss results. My husband also has taken it with zero side effects, by the way. So it became clear to me that the body's response to this medication is very individual.

How are you feeling today, wlb2?

@wlb2
I see the mentor has reached out to you.

I assume by the mention of introductory dose you are talking about the .25 which is the dose most doctors will start you off on so they can see how you react to the medication.

I had no significant side effects from the .25, .50. 1.75 until I hit the highest dose 2.25. I may be off on the exact numbers but as you can see they usually double each time you are on the dosage for a month.

Some individuals handle WEGOVY and some do not. That is why most doctors start you off with the lowest dose. As I mentioned until I got to the highest dosage, I only had bowel movement delay and a slight decrease in dinner appetite. Now when I got the highest dosage, I had a severe reaction. I vomited 3 times the day I took the dose and felt nausea for weeks after. Of course, my doctors said come off it as you have had a significant reaction. It took about a month to return to normal.

Now my primary care doctor wante me to try ZEPBOUND. It has to agents that affect your appetite versus WEGOVY only one. And I was told less side affects. But then I have read some have significant side effects with ZEPBOUND too.

It really depends on the individual. What and how one will react to any medication will not be the same to another. You have mentioned side effects that are common with WEGOVY. Just know that WEGOVY is going to slow down your digestive system. That for some is not an issue and get along fine. Some cite side affect more intense and significant issues.

WEGOVY had a web site and also a program for a mentor and advisor. I would go on the web site and sign up for that. You can talk directly to a rep.

Am I going to go on ZEPBOUND? No. I just have to learn to get my weight down and know that these weight loss drugs do work and many have had great outcomes, but you must stay on them to continue to get the benefit. Thus, long term lifestyle for me is to find a way to get my weight down and stay there.

I have had to accept that my personal techniques are not going to have the same quick weight loss success that others have had on WEGOVY has provided. But I have used techniques I have learned from my primary care doctor and web sites like WEB MD and they are working just at a much slower and much lower loss of weight each week.

Mayo had an excellent diet program also and you can go on the web site for that, and I believe there is a book on it as well.

So, my advice to you based on my experience is that if the side effects are something you want to deal with to get the weight off then you have to make that decision yourself. I did not like the side effects so I have accepted my weight loss will be slow and much harder, but my weight loss will be lifetime lifestyle and diet changes.

Have you tried weight loss programs like NutriSystem? I loss 60 lbs on that plan. My problem is got sick with COVID in 2023 that then went into sinus infection and then into bronchitis. I was down and miserable for 3 months and ate every comfort food I could find to feel better. So that is the weight I am not dealing with
Good luck!

@wlb2,
Weight loss drugs have side effects that may be temporary or last longer. Being nauseas is not why weight loss drugs work. The medications reduce appetite and increase feelings of fullness, some interfere with fat absorption in the intestines.,

This article may help with suggestions on side effects:
https://diet.mayoclinic.org/us/blog/2024/managing-common-side-effects-from-weight-loss-drugs/
If side affects do not reside, you should contact your provider about dosage adjustment.

Are you making lifestyle changes along with the weight loss drugs.