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davy80
@davy80

Posts: 4
Joined: May 05, 2016

Vectibix

Posted by @davy80, May 5, 2016

I am being treated for inoperable metastatic mesenteric cancer with the monoclonal antibody Vectibix. This is by iv infusion every two weeks. After 2nd session I have had many episodes of very low blood pressure(88/58) with extreme shortness of breath occurring when I do moderate activity. I’ve read that this is a side effect of Vectibix. Anyone else had similar experience and if so how did you deal with it?

REPLY

Welcome @davy80,
I understand that Vectibix (panitumumab) is only used in people who have the KRAS gene. For that reason, I’d like to introduce you to @sue_in_delaware. Sue just found out that she has the KRAS gene. She has colon cancer with mesenteric metastasis, but I don’t think she has taken Vectibix.

Davy, did your care team mention that the side effects may be cumulative?

@colleenyoung

Welcome @davy80,
I understand that Vectibix (panitumumab) is only used in people who have the KRAS gene. For that reason, I’d like to introduce you to @sue_in_delaware. Sue just found out that she has the KRAS gene. She has colon cancer with mesenteric metastasis, but I don’t think she has taken Vectibix.

Davy, did your care team mention that the side effects may be cumulative?

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Thanks for your reply. I have the wild type KRAS gene so Vectibix is
considered OK for my treatment. This is my 3rd time with intestinal cancer
since 2003.
I’m hoping to find how others have dealt with this side effects of lowered
bp, extreme shortness of breath and general tiredness.
Three days ago I received from my primary an IV infusion of a Myers
cocktail and these symptoms have been reduced. I will have another Vectibix
May 11 and another Myers IV the next day to see if it provides similar
benefits and will post results.

Liked by Sue

Yes, please post the results @davy80. I hope someone else will chime in with their experiences with Vectibix

While I haven’t yet found another Connect member who is undergoing treatment with Vectibix, we have several members who have had multiple dances with cancer. Let me introduce you to @travelgirl @neeter @hopeful33250 @barblacanne @ikampel2

Liked by Sue

@davy80 I did not receive Vectibix. I’ve been told it is not effective for the KRAS positive (gene mutation)
My blood pressure drops when I am dehydrated. Are you drinking 10 or more glasses of water a day? My BP was also low during the entire time I was having difficulty with too much diarrhea, but then, that does cause severe dehydration. (There’s probably a few other things and you should ask your doc. Let us know and keep us posted!)

@colleenyoung
Vectibix is used for wild type (or KRAS negative), people who do not have the gene mutation.
There are a lot of misunderstandings all over the internet forums. I’m still learning so much.

@sue_in_delaware

@davy80 I did not receive Vectibix. I’ve been told it is not effective for the KRAS positive (gene mutation)
My blood pressure drops when I am dehydrated. Are you drinking 10 or more glasses of water a day? My BP was also low during the entire time I was having difficulty with too much diarrhea, but then, that does cause severe dehydration. (There’s probably a few other things and you should ask your doc. Let us know and keep us posted!)

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I’ m drinking 10 to 12 12oz glasses of water/Gatorade in a 50/50 mix. I had
surgery March 8 which disconnected my small intestine from the large and
created an ileostomy. Staying hydrated is extremely important with this
condition.
My primary physician suggested that the surgery plus the Vectibix infusion
plus the 30# weight loss are all a strong demand on my system. He
recommended Myers cocktail IV. I had this last week and the symptoms I was
having were quite reduced. Not eliminated but reduced in both frequency and
severity. Unfortunately this is not covered by insurance and is $90/IV out
of pocket. But it did help and fortunately I can afford to do this every
two weeks. Hopefully this will continue to provide help through my next 6
Vectibix treatments.

@sue_in_delaware

@colleenyoung
Vectibix is used for wild type (or KRAS negative), people who do not have the gene mutation.
There are a lot of misunderstandings all over the internet forums. I’m still learning so much.

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I do have the KRAS wild type gene.

@sue_in_delaware

@colleenyoung
Vectibix is used for wild type (or KRAS negative), people who do not have the gene mutation.
There are a lot of misunderstandings all over the internet forums. I’m still learning so much.

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Thanks Sue. Wild type, positive, negative – it’s easy to see why there’s confusion on internet forums. Thanks for setting it straight here.

Liked by Sue

@colleenyoung

Yes, please post the results @davy80. I hope someone else will chime in with their experiences with Vectibix

While I haven’t yet found another Connect member who is undergoing treatment with Vectibix, we have several members who have had multiple dances with cancer. Let me introduce you to @travelgirl @neeter @hopeful33250 @barblacanne @ikampel2

Jump to this post

@davey80, I was diagnosed two weeks apart with two different cancers cecum and follicular lymphoma.
I was at Mayo Clinic earlier today and just under went testing for Lynch Syndrome.. I won’t know for a month as to the results. Based on what genetic testing finds out I guess that will determine how my future treatments will be handled. Having to deal any and all of this is nerve racking..

I wish you the best with your treatment..

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