Update on husband’s Extensive Stage SCLC and treatment

My husband was diagnosed with SCLC back in October, 25. It was originally in his right lower lung lobe a couple nodes and had Mets to liver, and three vertebrae in spine. No brain Mets on 2 previous MRI’s.He had 4 cycles etoposide plus carboplatin, and immunotherapy atezolizumab. Had CT which showed favorable shrinkage of lung tumor, not seen in nodes, minute mm left in liver and nothing showing on vertebrae. Then prophylactic brain radiation was given x 10 doses. There is what is called Hypocampus sparing brain irradiation, which ar the memory centers of the brain and we agreed only to have it done, if they could do this. His radiologist said they could and so went forward with it. His side effects were tiredness, hair loss and yes..short term memory loss. ( another discussion altogether!) He then continued with only the atezolizumab immunotherapy every 28 days. He was given 2 treatments and on April 27th, given a repeat CT of chest, abdomen and pelvis. New scan showed the immunotherapy did not work and original primary tumor was back, along with another behind 2 affected lymph nodes. It also showed some pleural effusion ( fluid in space between lung and pleural membrane). With collapse of right lung. He ended up in hospital with severe shortness of breath and home pulse ox of only 73%. He was in 2 days and placed on home oxygen 1-3 lpm. Now they are doing more radiation to his right lung mass, to try to clear his right bronchial airway so his breathing is better. Ordered to get 4 doses, which started today. The scariest part of all this is what is coming next. On Tuesday, he is supposed to report to the oncology department of the Taussig Cleveland Clinic Cancer center for an infusion of a new immunotherapy drug…Imdelltra ( Tarltamab) to be infused 1x/week x 4 weeks. The first two doses REQUIRE an overnight stay so he can be monitored for Cytokines Storm or ICANS ( neurotoxicity syndrome). These can both be life-threatening if they occur. If he tolerates it well, dose 3 and 4 can be given on outpatient and will get infused every 2 weeks thereafter. My husband’s overall health has declined some. He lost about 17 lbs since this started, mostly muscle mass and his COPD seems exacerbated. His appetite is just average to minimal. I think food puts pressure on his diaphragm, making it more difficult to breathe, so he avoids it, Most days he is pretty tired, has energy to walk around a store for 45 minutes but usually comes home and naps for short periods. He says he is not ready to “give up.” Wants to try this. I have my reservations but I don’t want to discourage him or put negative thoughts or fear into him. I did tell him at anytime, if he has side effects, he can stop.
Im sorry this is so long but just wanted to give an up day and put it out there for anyone else who may be dealing with this.
God bless you all and May he give you strength for your journey to fight this disease!
Donna