Ultra low Mammaprint Score - Aromatase Inhibitors
I’m bringing a more specific detail to the Aromatase Inhibitors discussions. Is there anyone here who has an Ultra Low Risk Mammoprint score who chose to forego endocrine therapy completely? I’ve reviewed the MINDACT and FLEX studies and I’m having a hard time convincing myself that taking an AI (specifically Letrozole) isn’t over treatment. Per the MINDACT study and my specific results, the difference in distant metastasis is negligible whether I take it or not. One oncologist is comfortable with my decision to forego and my second opinion wants me to give a try and see how I do. I’m 56, post menopausal and already deal with most of the issues listed as fairly common side effects. Invasive lobular Cancer Stage 1 HR+/HER2- with no node involvement. Anyone out there? It’s so hard to find anyone because standard of care is to take them for 5 years regardless and then decide whether longer is appropriate.
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It makes sense for you to weigh this decision. I've been on letrozole for almost four years with no side effects. Of possible interest to you, my oncologist said this might be because I've been dealing with chronic pain for decades and have good PT, exercise, and medication in place. You can of course just try letrozole and see. But if the oncologist says fine to skip that obviously would be an ok choice as well. Hope you get some specific info here.
I had 1.2cm had lumpectomy radiation Ki67 a (10) N nodes Oncoscore (3) Prog&Estro positive- I am 71 going by my genomic results I chose to forgo
any meds.