Never heard of that side effect, to be honest. I don't see how it could cause you to burn more calories? It could be coincidence. I would look for other reasons first. Change in eating habits? Dehydration? Hormone imbalance? Even something silly like an inaccurate scale can give you a bad weighing result,
You might want to have a full blood panel done to rule out any other potential issues. We get so caught up in our osteoporosis treatment that we sometimes forget that there are many other things that can go wrong with our health.
There is another thread on Mayo Connect that contains tons of comments about people on Tymlos having about a 10 lb weight GAIN esp in the abdomen area. This happened to me as well. I had not heard of a weight loss problem, but it makes sense if your appetite goes away. Unfortunately a lot of us have NOT changed a thing and have put on 10lbs since starting Tymlos.
I started taking Tymlos in October 2025 and now in January 2026 I find that I have lost 8 lbs. As a 5’11” small boned 66 yo female, I should NOT weigh 117lbs.
I still have not worked my way up to the full 80 dosage. I’m currently at 50. I’ve never had weight issues because I’m a runner. But my doctor insists I continue because as far as he knows, weight loss is not a side effect.
I think he needs to read more about this drug.
@lightlifts
I’m thinking that the weight loss could be related to mildly high
calcium levels. I just got blood and urine test results back from my physical which indicate this.
Hypercalcemia can cause weight loss from what I understand.
I’ll obviously have to talk to my doctors about this.
I started taking Tymlos in October 2025 and now in January 2026 I find that I have lost 8 lbs. As a 5’11” small boned 66 yo female, I should NOT weigh 117lbs.
I still have not worked my way up to the full 80 dosage. I’m currently at 50. I’ve never had weight issues because I’m a runner. But my doctor insists I continue because as far as he knows, weight loss is not a side effect.
I think he needs to read more about this drug.
@kittygrrrl I experienced some nausea and reduced appetite when I began Tymlos. In about 5 months I lost around 15 pounds—no dieting. It was a bonus—I needed to lose weight. The doctor gave me med for the nausea—which lasted a couple of months. By the end of my Tymlos 2 years—I had regained about half of weight lost. Hope you can get back to your normal weight! Hang in there!
I started taking Tymlos in October 2025 and now in January 2026 I find that I have lost 8 lbs. As a 5’11” small boned 66 yo female, I should NOT weigh 117lbs.
I still have not worked my way up to the full 80 dosage. I’m currently at 50. I’ve never had weight issues because I’m a runner. But my doctor insists I continue because as far as he knows, weight loss is not a side effect.
I think he needs to read more about this drug.
@kittygrrrl I experienced some nausea and reduced appetite when I began Tymlos. In about 5 months I lost around 15 pounds—no dieting. It was a bonus—I needed to lose weight. The doctor gave me med for the nausea—which lasted a couple of months. By the end of my Tymlos 2 years—I had regained about half of weight lost. Hope you can get back to your normal weight! Hang in there!
@niifty1 I've been on tymlos for 9mo actually gained weight. They then put me on hydrochlorothiazide to lower water gain. Hope tymlos worked for you. I haven't gotten any test results to check mine yet
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Never heard of that side effect, to be honest. I don't see how it could cause you to burn more calories? It could be coincidence. I would look for other reasons first. Change in eating habits? Dehydration? Hormone imbalance? Even something silly like an inaccurate scale can give you a bad weighing result,
You might want to have a full blood panel done to rule out any other potential issues. We get so caught up in our osteoporosis treatment that we sometimes forget that there are many other things that can go wrong with our health.
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1 ReactionThere is another thread on Mayo Connect that contains tons of comments about people on Tymlos having about a 10 lb weight GAIN esp in the abdomen area. This happened to me as well. I had not heard of a weight loss problem, but it makes sense if your appetite goes away. Unfortunately a lot of us have NOT changed a thing and have put on 10lbs since starting Tymlos.
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2 Reactions@kittygrrrl I have Gained 7lbs on it for 5 months. .5 side effect. Hope you get to the bottom of this. I am very unhappy with the weight gain
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2 Reactions@lightlifts
I’m thinking that the weight loss could be related to mildly high
calcium levels. I just got blood and urine test results back from my physical which indicate this.
Hypercalcemia can cause weight loss from what I understand.
I’ll obviously have to talk to my doctors about this.
-
Like -
Helpful -
Hug
1 Reaction@kittygrrrl I experienced some nausea and reduced appetite when I began Tymlos. In about 5 months I lost around 15 pounds—no dieting. It was a bonus—I needed to lose weight. The doctor gave me med for the nausea—which lasted a couple of months. By the end of my Tymlos 2 years—I had regained about half of weight lost. Hope you can get back to your normal weight! Hang in there!
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Hug
1 Reaction@kittygrrrl I started Tymlos June 2025. I have lost 20 lbs.
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1 Reaction@cherlynn2
Have you been checked for hypercalcemia?
That in itself may cause weight loss.
@niifty1 I've been on tymlos for 9mo actually gained weight. They then put me on hydrochlorothiazide to lower water gain. Hope tymlos worked for you. I haven't gotten any test results to check mine yet
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