Triple Negative Breast Cancer: What treatments are you having?

Posted by thielmann1 @thielmann1, Dec 9, 2021

I have just been diagnosed with Triple Negative Breast Cancer after having Estrogen Positive Breast Cancer for 21 years. Is anyone familiar with this diagnosis and treatment that you are having for it?

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@gbnana

I so appreciate your reply to me especially while you are going through such a painful ordeal!
You are very brave to go through those treatments. You must be a fighter and it sounds like you will knock this cancer OUT!
Its been 7 months since mastectomy and I am afraid!

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Thank you 🙏🏼🙏🏼

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@leolion811

My reoccurrence was found in my bilateral 6 month ultrasound (diagnostic mammogram didn’t find it) Same cancer and localized as the 1st time. Had a right auxiliary lymph node dissection. (5 lymph nodes removed) inconclusive- cancer Not in lymph nodes but in the tissue around one lymph node. I am In the middle of taking Gemzar/Carboplatin- 3 more treatments left. This regimen is worse than the Red Devil and Taxol. Spent 9 days in hospital due to dangerously low platelets and WBC counts. Had 3 blood transfusions and daily Zarxio injections.. and now my Gemzar/Carbo doses are 20% reduced. And then my port stopped working. Had to be removed & replaced , then both incisions became infected. Absolutely horrible. After chemo, I will have 25 rads with No boosts.

Jump to this post

I so appreciate your reply to me especially while you are going through such a painful ordeal!
You are very brave to go through those treatments. You must be a fighter and it sounds like you will knock this cancer OUT!
Its been 7 months since mastectomy and I am afraid!

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@gbnana

Sad to hear of your reocurrence and I pray that it will be treated and you will be back to good health again quickly
I worry every day about my triple neg coming back.
Where did it reoccur?
How did you discover it?
What treatment will you have?

Jump to this post

My reoccurrence was found in my bilateral 6 month ultrasound (diagnostic mammogram didn’t find it) Same cancer and localized as the 1st time. Had a right auxiliary lymph node dissection. (5 lymph nodes removed) inconclusive- cancer Not in lymph nodes but in the tissue around one lymph node. I am In the middle of taking Gemzar/Carboplatin- 3 more treatments left. This regimen is worse than the Red Devil and Taxol. Spent 9 days in hospital due to dangerously low platelets and WBC counts. Had 3 blood transfusions and daily Zarxio injections.. and now my Gemzar/Carbo doses are 20% reduced. And then my port stopped working. Had to be removed & replaced , then both incisions became infected. Absolutely horrible. After chemo, I will have 25 rads with No boosts.

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I'm 2 years into my 5 years, baseline here at UCLA is an MRI with contrast every year, and a mammogram every year – staggered so you are getting one or the other every 6 months.

I had a PET CT scan at the end of active treatment, and have three months follow-ups with my oncologist for blood work tracking tumor markers.

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@callalloo

The article that I posted above addresses the difference in the pattern of recurrence for triple negative compared to ER+ breast cancer.

"Many triple-negative breast cancers differ significantly from hormone-positive tumors in that they are less likely to recur late, that is, five or more years following diagnosis.

With estrogen-receptor-positive tumors, the incidence of recurrence remains steady for at least 20 years following the diagnosis, even for very small, early-stage tumors. In fact, people who have estrogen-receptor-positive early-stage breast cancer are more likely to have a recurrence after five years than in the first five years following diagnosis.

In women with hormone-positive tumors who are treated with hormonal therapy for five years after surgery and/or radiation/chemotherapy, the distant recurrence rate between year five and year 20 ranges from 14% for small, node-negative tumors (T1N0) to 47% for larger tumors that have spread to lymph nodes (T2N4-9).8

The lower incidence of late recurrence with triple-negative breast cancer wasn’t as clear until recently, as many studies only went out five years when looking at recurrence and survival.

A 2018 study, however, looked at people with triple-negative breast cancer who were disease-free five years after their diagnosis. Among this group, the 10-year recurrence-free rate was 97% and the 15-year recurrence-free rate was 95%."

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What is the rate of reoccurrence in the first 5 years with Triple Negative? What imaging and monitoring is normally done during those 5 years?

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@auntieoakley

As I understand it, with triple neg it is a matter of druggable targets and being able to truly get rid of it in the first place. This is the biggest problem that researchers I have met want to solve. I do know for positive there is literally an army of doctors and researchers working on this, and things are getting better all the time. The same is true with the her2, oncotype which is truly an aggressive form because of the way it grows. I would love to read anything that says triple neg is less likely to recur. That would really bring me joy.
How are you feeling with all of your treatments?

Jump to this post

The article that I posted above addresses the difference in the pattern of recurrence for triple negative compared to ER+ breast cancer.

"Many triple-negative breast cancers differ significantly from hormone-positive tumors in that they are less likely to recur late, that is, five or more years following diagnosis.

With estrogen-receptor-positive tumors, the incidence of recurrence remains steady for at least 20 years following the diagnosis, even for very small, early-stage tumors. In fact, people who have estrogen-receptor-positive early-stage breast cancer are more likely to have a recurrence after five years than in the first five years following diagnosis.

In women with hormone-positive tumors who are treated with hormonal therapy for five years after surgery and/or radiation/chemotherapy, the distant recurrence rate between year five and year 20 ranges from 14% for small, node-negative tumors (T1N0) to 47% for larger tumors that have spread to lymph nodes (T2N4-9).8

The lower incidence of late recurrence with triple-negative breast cancer wasn’t as clear until recently, as many studies only went out five years when looking at recurrence and survival.

A 2018 study, however, looked at people with triple-negative breast cancer who were disease-free five years after their diagnosis. Among this group, the 10-year recurrence-free rate was 97% and the 15-year recurrence-free rate was 95%."

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Sad to hear of your reocurrence and I pray that it will be treated and you will be back to good health again quickly
I worry every day about my triple neg coming back.
Where did it reoccur?
How did you discover it?
What treatment will you have?

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@leolion811

TNBC is most aggressive breast cancer out there. I am dealing with a reoccurrence only after 2 and 1/2 years after my original TNBC.

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Thank you 😊

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@cindyjoan

I was diagnosed with Stage 3b triple negative Invasive Ductal carcinoma with a ki-67 of 95% in April. Started 6 months of chemo in May, then surgery and radiation. Then a year of immunotherapy. I was surprised to read the comment above that there was a high recurrence of triple negative because I read an article recently that there was a lower recurrence in triple negative. Unfortunately I can't remember where the article was from.

Jump to this post

As I understand it, with triple neg it is a matter of druggable targets and being able to truly get rid of it in the first place. This is the biggest problem that researchers I have met want to solve. I do know for positive there is literally an army of doctors and researchers working on this, and things are getting better all the time. The same is true with the her2, oncotype which is truly an aggressive form because of the way it grows. I would love to read anything that says triple neg is less likely to recur. That would really bring me joy.
How are you feeling with all of your treatments?

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I think there's a difference between how aggressive a cancer is and its likelihood of recurrence. The article linked below gives some clarification. As with anything related to breast cancer, treatment options and plans are changing all the time as new tools become available or improved. So keep in mind that any statistics collected over time, say 10 years or so, can include data on earlier patients who had different more-limited treatment options vailable at the time. And might include patients whose cancer was found later than they are now since older women did not routinely have mammograms in the past.

Basically most newly-discovrered breast cancers today have better overall prognosis in general because of advances in treatment options. I like to stress this as it's both true and encouraging when considering 'statistics.'
https://www.verywellhealth.com/triple-negative-breast-cancer-prognosis-4778440

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