I am a firm believer in Zometa (let me just say that out of the gate). I had the attitude that I would do anything to increase the risk of recurrence, anytime, anywhere (and that's one of them). The major downside is the inability to receive dental care while on it (at least around here). I finished my 6th infusion 6 months ago, and will be going to a med/dental hospital for overdue oral surgery (secondary to the chemo I had in 2019). My oncologist wanted me to wait a full 6 mos. Yes, Zometa has recently been shown to have tumor suppression properties in the bone. Initially it was prescribed for bone strength.