Treatment for Prostate Cancer Metastasized to Bones

Hi the 3 therapy combination results are in the arasen clinical trial, by combining the 3 therapies at once prognosis is expected to be much better, goole arasen clinical trial results

best

agustin

HI, could you please post what the three therapies are?

Docetaxel + Lupron + 2nd Generation ADT drug (nubeqa, others....)

I would like to know as well as they plan chemo from me Apparently Xtandi slowing down working they say Nuclear scan Oct 17th
PSA 3.4

I was on ADT and Erleada for 13 months. I was tired all day and slept poorly at night. I also had depression. I have been off of meds for 10 months, feel so much better, PSA .01, testosterone 124. Cancer is sleeping and I am doing my best not to wake it.

Hi @thor65, you might wish to explore the experiences shared in these discussion related to darolutamide (Nubeqa):
- Nubeqa and Lupron
https://connect.mayoclinic.org/discussion/nubeqa-and-lupron/

- Have you used Nubeqa or Zytiga?
https://connect.mayoclinic.org/discussion/have-you-used-nubeqa-or-zytiga/

Hi @jas1961, how did your husband's first chemo treatment go? How are YOU doing?

Everybody's prostate cancer journey will be different. Here's mine.

I'm 58, and have been living with advanced prostate cancer for two years. I walked into hospital because I had a (minor) back pain, was staggering sideways, and my toes were numb -- I thought it was a pinched nerve. After 5 days (during which I was getting CT scans, MRI, x-ray, biopsy, etc etc) I suddenly found myself paralyzed from the bottom of the ribs down, so they rushed me into the OR for about 12 hours of emergency debulking surgery on the tumour they'd found on my spine at T3.

I ended up spending 3 1/2 months in hospital and rehab, and came home still in a wheelchair. I had radiation both to my spine and prostate, and have been on Degarelix (Firmagon) and Apalutamide (Erleada), which quickly reduced my PSA to undetectable levels and have held it there. Reading about the Titan study for Apalutamide with metastatic castrate-sensitive prostate cancer gave me my first bit of hope at a dark time (it was so successful that they unblinded the study partway through and gave the placebo group the option to get the real medication). A bone scan right after surgery showed no other metastases, so they've classified me as "oligometastatic" and (apparently) administered a curative rather than palliative radiation dose to my prostate, so I know they have some hope as well.

It's hard to separate side-effects of my meds from the spinal damage and rehab. After two years of hard physio, and I can walk again (I still have to be careful not to stagger) and even cycle, but I have imperfect sensation below my rib cage, and am not always sure what I'm feeling. There's damage to the very bottom of my bladder near the prostate from my radiation -- I saw it myself on the screen during a cystoscopy -- which means that I usually have traces of blood in my urine and experience bladder pain if I get dehydrated or overdo it on irritants like caffeine, alchohol, spicy food, or carbonated drinks.

As for the original question, yes, I experienced a lot of fatigue at first, but I don't know how much was from meds and how much was from spinal damage and 2 hours of physio/day. The fatigue has diminished considerable as I've regained mobility, so I guess I'm lucky, and as long as my quality of life is good (much better than I'd expected during those months lying paralysed staring at the ceiling of a hospital room) and the meds are keeping the cancer dormant, I agree with my oncology team not to try to fix what ain't broke.

At first, my oncologist talked about 5 years (which would be scary, since I'm almost halfway through); now the head of the team is suggesting 10+, possibly with no chemo or other treatment needed during that time. We'll see. My first goal is to make it to 65. Age 70 would be great, but I'm not getting my hopes too high yet. I just lost a friend who had been doing much better than me until the last few months to lymphoma (we'd been getting together and supporting each-other), so I know how fast things can turn. But I'm grateful for every day, and especially grateful for the great medical care I'm getting here in Ontario.

On Xtandi Xgeva and Zolodex Mets in T 10 11 and L2 which was nucked in 2020 Its back in L 1

PSA up again to 4.1 Looking at next steps Chemo Clinical trial or ??

Help 79 feel great

Good Luck North. I was on Erleada and ADT in a clinical trial for 13 months ( surgery too). The meds certainly made me tired and I slept poorly. 2 years ago my doctor gave me 2-4 years but I have been off of meds for 10 months and my PSA has remained at .01 and testosterone rising in 10 months to 125. I have recently switched to a vegan diet and I hope that this might help. Feeling really good now. I think that I might be doing better than expected and I will visit with my surgeon in a month and inquire if he might up my prognosis. Good luck to us all!