Tramadol and bone pain
My pain mgmt doctor rx'd tramadol. I take one at bedtime. For 2 nights I fell asleep before taking the tramadol, and next day felt very depressed for no reason. That night I took the tramadol and next day depression was gone. I'm wondering if the depression was caused by missing the medication? I should mention the bone pain is from chronic blood cancer (essential thrombocythopenia)
Interested in more discussions like this? Go to the Chronic Pain Support Group.
Connect

I take Tramadol and never notied a connection. I get a couple hours of small "feels good" boost in the morning and that's it.
@1995victoria Yes, some people do feel depression when stopping tramadol. And recent research indicates tramadol use may increase risk of depression
https://www.sciencedirect.com/science/article/abs/pii/S0165032726005665
You might want to ask your doctor about this, especially if it happens again.
@sueinmn
In the past I've quit Tramadol cold turkery and never felt depressed.