1. < Blood Cancers & Disorders
Profile picture for mjbulte

TKI vs Hydroxyurea

Posted by mjbulte @mjbulte, Jul 27 8:18am

What happens when you switch from Hydroxyurea to a TKI medication? Looking to likely switch and want to know what to expect. Am tolerating Hydroxyurea very well, so anxious about switching.

Interested in more discussions like this? Go to the Blood Cancers & Disorders Support Group.

Profile picture for mjbulte
mjbulte | @mjbulte | 13 hours ago
In reply to @loribmt "Hi @mjbulte. I don’t have any personal experience with Danziten but a little sleuthing this morning..." + (show)
Profile picture for Lori, Volunteer Mentor @loribmt

Hi @mjbulte. I don’t have any personal experience with Danziten but a little sleuthing this morning shows it’s a revised version of Nilotinib (Tasinga) which you mentioned.

Here’s the briefing from Azurity Pharmaceuticals:
https://azurity.com/azurity-pharmaceuticals-inc-announces-fda-approval-of-danziten-nilotinib-tablets-the-first-and-only-nilotinib-with-no-mealtime-restrictions/
I haven’t found any members specifically mentioning Danziten yet. But since it’s a relatively new drug on the market it may take a little time for more replies to trickle in.
Fingers crossed for the drug approval! In the meantime, are you still taking the HU?

Jump to this post

@loribmt
I started Danziten (half dose) last week. So far no severe side effects, just a bit more fatigue than normal and inflammation if I eat sugar. Blood work to be done soon and that should show how well, or not, this medication is working. So far, I haven’t heard from anyone who is taking Danziten. I’m feeling like a guinea pig!

REPLY
1 reply
Profile picture for Lori, Volunteer Mentor
Mentor
Lori, Volunteer Mentor | @loribmt | 11 hours ago
In reply to @mjbulte "@loribmt I started Danziten (half dose) last week. So far no severe side effects, just a..." + (show)
Profile picture for mjbulte @mjbulte

@loribmt
I started Danziten (half dose) last week. So far no severe side effects, just a bit more fatigue than normal and inflammation if I eat sugar. Blood work to be done soon and that should show how well, or not, this medication is working. So far, I haven’t heard from anyone who is taking Danziten. I’m feeling like a guinea pig!

Jump to this post

@mjbulte I was looking for an emoji of a guinea pig. 🐹☺️
Even though the Danziten you’re taking is relatively new there’s the reassurance that its foundation is an effective drug that was approved by the FDA in 2007 (nilotinib/Tasigna). Just modified so that you don’t have to fast before taking.
Reading the info on both drugs I can see why there would a push to redesign it. Having to fast 2 hours before and 1 hour after taking Tasinga (every 12 hours) would get pretty old leaving it a challenging schedule to adhere to.

Your comment about sugar and inflammation is really interesting. I’ve found the same thing too. I tend to stay away from any excess sugars and starchy foods. But if I have a moment of indiscretion…oops! 😅 I seem to pay for that with not feeling my usual perky self the next day. Our diets really do make a difference. Ho hum…but sometimes I just need to indulge in dark chocolate…

Will you let me know how your labs turn out?

REPLY
View MoreView Less
Please sign in or register to post a reply.