The lowest effective dose, how is it defined?

Posted by megz @megz, Aug 6, 2023

Since starting on 15mg of prednisolone for PMR on 10th May (12wks ago), my sole focus has been to "reduce to the lowest effective dose in the shortest possible time" as per the drug company's directive to minimise side effects and reduce the overall cumulative dosage.

I'm now at 8mg and the pain has returned after practically no pain, It's at tolerable levels but disappointing after having been pain free. I assume I've reached the lowest effective dose, or maybe overshot it by 1mg by reducing so quickly. So what is an "effective" dose?

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megz | @megz | 1 day ago

In reply to @heals1225 "Thanks @megzeng I’m all in with this, and hope it’s the final schedule for both of..." + (show)

That's what I hope too! I'm hoping the small daily fluctuations while reducing more closely mimic natural daily cortisol fluctuations so we can sneak past the body's patrol system. "Is everything okay here guys? Yeah, looks fine and normal. No need to roll out the alarm response, business as usual." 🙂