Testosterone levels are rising after cessation of ADT

Take this with a huge grain of salt (I'm not a medical professional), but I think the point of stopping ADT with earlier-stage prostate cancer is to let your testosterone come back to get rid of the side effects. What you *don't* want to see come back is the PSA.

rising testosterone after ADT is normal. When I was on ADT my T went to 9. I have been meds free for 20 months and my T has increased to 100, which is still low. It may be low due to my new plant based diet, I don’t know, but low T is something that I am pleased with. Low T may adversely effect my ED and muscles etc but staying alive is a higher priority for me

What ADT protocol were you on?

I’m not a medical professional, just a fellow prostate cancer patient and my opinion is rising testosterone without rising PSA sure sounds like a good deal to me.

How to use Lupron Depot (3 Month) 22.5 Mg Intramuscular for 2 years

I was on Lupron shots and Erleada pills for 13 months and I was monitored every 3 months. PSA went to and stayed at .01 and T was at 9 and now 100 . G9, advanced, aggressive, high risk but presently doing good and hope to stay that way!

God bless you man! Keep the faith and never give up!

Your PSA remaining undetectable as your T rises is a very good thing.

I was on Lupron for one year as part of triple therapy for oligometastatic prostate cancer. While on Lupron my T was < 3. My last 3 month Lupron shot was one year ago. My most recent PSA/T labs show continued PSA < 0.014 (great!) but my T has only gotten up to 33.

Your question raises an interesting question...First, my clinical history (see attached).

After finishing triplet therapy with my last 90 day Lupron shot in May 18, my T rose to 135 by October then 481 by February, eventually 608 in March 2023 when we started back on treatment. After stopping Orgovyx on 3 April after a year, 90 days later T is 328, PSA .001, side effects, gone.

How long will this "vacation" last, who knows but I feel great!

I pondered, well, mused with my medical team, why, if T is the fuel for PCa, did my PCa not "return" until 2022 when it began its rise from .06 to ,77 a year later? The other question we pondered is why my T recovered so rapidly and higher, considerably, than when I started triplet therapy which was 297 when tested at Mayo.

No definitive answer.

As other have said, I'm a layman, no formal medical training, education, or board certifications.

What I do know is the side effects dissipated, hot flashes, fatigue, muscle and joint stiffness and genitalia shrinkage.

So, enjoy, continue to actively monitor your PSA, T and other blood values as appropriate.

Kevin

I am grateful to have discovered this site for prostate cancer support .
You gain confidence in preparing for the next clinical visit because you have information on your current health status…supported by others in a similar situation👍