Taking acyclovir daily for recurrent HSV-2 flares

Posted by vcastaldo @vcastaldo, Jan 13, 2022

I was diagnosed with HSV-2 almost 20 years ago. I was having a flare every now and then and was prescribed acyclovir 400 mg 3 times daily for 5 days. For the past couple of years, I have had about 11-12 flares per year. I am aware that stress is my trigger. My doctor is now saying that I should take acyclovir every day from here on out. I feel uncertain about this. I have tried to remain calm and stress-free; however, the virus seems to be getting worse and not better. I've already had 2 flares this year and it's only 13 days in. Just wondering if there are others who take acyclovir on a daily basis and if there are any issues with doing so.

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Well, stress has certainly been our constant companion these past 2 years, so I guess increased episodes should not be a surprise. Here is what Mayo Clinics have to say about long-term Acyclovir. I guess I am lucky that I only need it a couple of times each year.
I am only speculating here, but if you have taken it so often without serious side effects, it should probably be okay. Just be sure to mention it if any new medications are prescribed for you.
Have you discussed your concerns with your doctor?


I was told by an immunologist in Boston that as you get older you can have more flares. Never heard of that but I also have MGUS so my immune system is weaker. I took it daily for over a year, no issues. I recently stopped taking it because when I was traveling and didn’t have it with me I noticed my dry eye condition significantly improved. I did have a flare shortly after I stopped it, so taking one day at a time right now.

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