Switching from one GLP-1 RA to another?
I started on zepbound (tirzepatide) in a quest to reduce the pain of my knee arthritis -- buy time before replacing the joint -- which worked, but triggered a number of side effects that eventually became intolerable. Switched to ozempic (semaglutide). On the plus side, this really did reduce the side effects. (It helped that it's a multipen, which means I could click-dose.) On the minus side, apparently arthritis is emerging as a semaglutide side effect, and it may be one of mine. Everything else is going well, but the arthritis symptoms are coming back. So I'm thinking about switching again, if my orthopedist confirms that this is what's going on. I can go back to tirzepatide, or consider one of the older GLP-1RAs, like exanatide XR or dulaglutide. Or I could wait it out, and switch to a new product now in the pipeline when it becomes commercially available. Or I could get really creative, and alternate 6 months on semaglutide and 6 months on tirzepatide. Or something. Anyone else have experience with switching between these meds or thoughts on how to approach this problem?
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