Something new in the treatment arsenal?
AstraZeneca reported positive results from a Phase 3 trial for a breast- cancer treatment, sending its American depositary receipts higher.
Shares of AstraZeneca (ticker: AZN) were up 1.7% to $68.16 in morning trading.
The company said the trial showed that the treatment, datopotamab deruxtecan, showed a significant improvement relative to chemotherapy in terms of progression-free survival. Plans to submit the drug for regulatory approval globally are underway.
Progression-free survival “is defined as the time from random assignment in a clinical trial to disease progression or death from any cause,” according to the National Library of Medicine.
Interested in more discussions like this? Go to the Breast Cancer Support Group.
Hi Zebra. I took Kisqali in 2019 and don't remember the dosage. The first indication of eye infection was feeling of having an eyelash in my eye, then progressed to sensitivity to light. The second eye infection I knew right away but I was in a small mountain town with no care nearby. My eye teared up so badly it was running through my nostril, lol. I have been on Truqap since mid January and am feeling well although this drug has a tendancy to cause diabetes. So I have been buying the Libre 3 constant glucose monitor and I do have elevated levels when taking the pills (800 mg daily for 4 days then off for 3 days). I have a pet scan scheduled later this month, hoping for good results!
Hi @vicsmit
Just reading your post here. I'm so sorry about what happened to you with Kisqali! That's awful! I've been on Kisqali for 3+ years now. Do you happen to remember what dose you were on during the trial? What were the first issues you noticed with your eyes?
How is Truqap working for you? Are you finding the side effects tolerable?
Prayers for you for all of this. Zebra
Hi @leeann66
Thank you for the update! Prayers for your scan results! Please update when those come in. It sounds like you're still in good spirits despite some challenging side effects. Yes, neat how they are treating your eyes. New treatments all the time. Also good news that they are submitting Dato-Dxd for FDA approval. Your results to date are encouraging!
Since you're so great about answering questions:
Do they expect you to remain on Dato-Dxd indefinitely or only when there are visual signs of cancer?
Have there been any issues with Dato-Dxd causing peripheral neuropathy as many chemos do?
For perspective, how much does this treatment impact your quality of life compared to the other treatment regimens you've tried (Kisqali/anastrozole, afinitor/exemastane, xeloda)?
Thank you for taking the time to respond. Please keep us posted. Zebra
Hello, yes all is well! I was
Locked out of this channel
For awhile so was not responding or commenting.
Just had a scan yesterday so will know if all is still stable.
I don’t remember my last update however side effects, specifically my eyes and mouth and more fatigue.
My “dry eye”
Kept getting worse and worse so I pushed for further testing and was diagnosed with Limbal Stem Cell Deficiency caused by the chemo. On special eye drops made from the plasma from my own blood (pretty cool) since end of January and seeing slow progress, but still progress! (Maybe I already shared that here???)
Mouth sores, well that also got worse and I am expecting a new diagnosis on that also (following my constant research to find solutions and sharing my findings with my medical team!). All issues chemo related!!
Anyways, I have no reason to believe the cancer is not still stable and will know for sure this coming week! 🤞🏻
I also saw that Dato-Dxd was being put forward in the US for FDA approval so will soon be available for everyone!
If you have any specific questions please reach out to me I’d be happy to share!
Thanks for reaching out, will try to remember my password moving forward so I can continue to be active in this forum! 😀
Hi @leeann66 The last post I see from you is 4 months ago. Are things still going well in the clinical trial? I would love to hear an update on how you're doing. Zebra
I have HR+ HER2- mbc and had been on Verzenio for 6 months then Abraxane chemo for 6 months before each began losing effectiveness. My oncologist is prescribing a newly approved immunotherapy pill called Truqap produced by AstraZenica. I have not started this treatment yet but reading indicates side effects similar to Verzenio et al. My oncologist said Truqap is not in the same family as Verzenio et al though. As a side note, I was also in a Kisqali trial during 2019-2020 before losing my eyesight to corneal damage caused by bacterial infections in each eye 6 months apart (I add this to warn users to be aware of any eye sensitivity and see your optometrist immediately). Here is a link to more information on Truqap https://www.astrazeneca.com/media-centre/press-releases/2023/truqap-approved-in-us-for-hr-plus-breast-cancer.html
Nlb122– what type of breast cancer are you being treated for?
Anything new for TNBC? Thank you.
Greats news that the trial is going so well for you!!! Thanks for the update. Prayers for continued success!!!
Hello! Yes I got the results and everything is still stable, no changes meaning no new lesions, cancer not seen in all
The previous places, still
Showing in the lymph nodes but has not changed in size for 6 months. (Initially they shrunk to half the size but have not changed since!). Overall very good news!!!! Thanks for checking in! 😀