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Smoldering Multiple Myeloma (SMM). Questions and Answers

Posted by DMD81 @dmdinapoli81, Dec 6, 2025

I wanted to start a discussion specifically on SMM. Asking specific questions about time of diagnosis, like age, m-spike level, protein in urine level and % of bone marrow involvement. If you had MGUS prior to diagnosis? Any bone or joint paint? What your Hem-onc has as your monitoring schedule? Etc.

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righty01 | @righty01 | Jan 25 8:16am
In reply to @donna195 "@dmdinapoli81 , i have had SMM since May 7, 2025 with 20-30% plasma cells with a..." + (show)
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@dmdinapoli81 , i have had SMM since May 7, 2025 with 20-30% plasma cells with a lambda restriction, 2.2 g/dl monoclonal protein and flc ratio less than 0.1 on bmb. Lambda is very high 631 and Kappa is very low 35.

My hematologist ordered a repeat serum flc this week and I have a repeat bmb on Christmas Eve. My last two MRIs showed 2 focal enhancements, 5 mm x 8 mm and 5 mm x 6 mm. There is a 3rd that us 4 x 4. None of these areas showed up on July PT CT scan. We are discussing start of treatment to slow progression after we see results of new tests.

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@donna195 did your BMB include a FISH panel? Any chromosome abnormalities?

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DMD81 | @dmdinapoli81 | Jan 25 9:37am

@righty01 @donna195
Dr. Sikander Ailawadhi from the Mayo Clinic explains the monosomy 13 marker, chromosome mutations, and how specialists locate high-risk markers. Check out what he has to say. It’s interesting. No one thing to mention having chromosome mutations or deletions can increase your risk factor, but I think are more important once it has progressed and with medical advancement, they found ways to reduce those initial thought risk factor

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donna195 | @donna195 | Jan 25 1:14pm
In reply to @righty01 "@donna195 did your BMB include a FISH panel? Any chromosome abnormalities?" + (show)
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@donna195 did your BMB include a FISH panel? Any chromosome abnormalities?

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@righty01
Yes it included a FISH panel and no abnormalities. I was just hospitalized for 9 days from a strange infection that was abscessed in my right neck cavity. my immune system is a little weak right now. Hoping to get some answers from ENT, infectious disease and hematology/oncology follow ups after i finish remaining antibiotics.

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