What experience has anyone had with the Signatera blood test?

Posted by babab @babab, Aug 19, 2024

What experience has anyone had with the Signatera blood test. My results have been 0.13, 0.15, and now 0.17.

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jaxfl | @jaxfl | Sep 25, 2025

Rash is down significantly. As is the itching. Bloodwork today showed my eosinophils skyrocketed to 0.69 and 13%. Also an unexpected signatera draw.

@141emp: I am losing pigment in tiny spots on my arms and legs.

141emp | @141emp | Sep 24, 2025

In reply to @jaxfl "I can imagine. The rash is moving all over my body. Plus I have some tiny..." + (show)

@jaxfl my reactions have been pretty consistent from cycle to cycle. Sounds like the skin reactions are different for everyone I know on this. I look sunburned and have an eczema type rash in many places, some people don’t have any , some lose pigment. It’s not fun, that’s for sure but I’m grateful it seems to be working. Wish you the best!

ronzee50 | @ronzee50 | Sep 24, 2025

In reply to @141emp "Natera has amazing technology but very poor operations and customer service in my early experience. I..." + (show)

My second test went smoothly. Naturally requested another blood sample before I received the results from the first test. I had my blood draw at home. Everything progressed as it should have. There were notifications of the receipt of the blood sample, an estimate of when the results would be ready, and notification given of the results. I did not have to contact anyone this time.

fos | @foss | Sep 24, 2025

In reply to @ronzee50 "So far, not a good experience with Natera. It started off fine. Mayo sent the tissue..." + (show)

Tried them all. Found Coloplast the best. Been using that product for several years now. No problems. Foss

jaxfl | @jaxfl | Sep 23, 2025

I can imagine. The rash is moving all over my body. Plus I have some tiny weird loss of pigmentation in some spots now.

141emp | @141emp | Sep 23, 2025

In reply to @jaxfl "Yes. I am also using triamcinoline acetonide cream usp 0.1%. The rash is now almost gone..." + (show)

I won’t know until after next pet scan and Signatera mid October. My side effects are tolerable for the time being although I struggle the most with eating. I’m eating a lot less than I was before treatment which is not necessarily a bad thing and still get hungry. There is very little that tastes anything like it should. Tough for a foodie that loved to cook.

jaxfl | @jaxfl | Sep 18, 2025

Very much so.

jowilliams1 | @jowilliams1 | Sep 17, 2025

In reply to @jaxfl "The rash escalated to my sides, chest and back. I received a topical steroid. It is..." + (show)

Oh that sounds uncomfortable!

jaxfl | @jaxfl | Sep 17, 2025

Yes. I am also using triamcinoline acetonide cream usp 0.1%. The rash is now almost gone from the chest and back but more noticeable on the sides.

Hang in there! Is your oncologist considering deescalating to just pembro after six EVP cycles? That appears likely based on your commentary.

141emp | @141emp | Sep 17, 2025

In reply to @ronzee50 "Finally got my results from Natera after three months of waiting. The first samples from Mayo..." + (show)

Natera has amazing technology but very poor operations and customer service in my early experience. I almost refused to use them until my new surgeon personally assured me everything would be handled his office. He didn’t let me down. There were no problems.