What experience has anyone had with the Signatera blood test?

My second test went smoothly. Naturally requested another blood sample before I received the results from the first test. I had my blood draw at home. Everything progressed as it should have. There were notifications of the receipt of the blood sample, an estimate of when the results would be ready, and notification given of the results. I did not have to contact anyone this time.

Tried them all. Found Coloplast the best. Been using that product for several years now. No problems. Foss

I can imagine. The rash is moving all over my body. Plus I have some tiny weird loss of pigmentation in some spots now.

I won’t know until after next pet scan and Signatera mid October. My side effects are tolerable for the time being although I struggle the most with eating. I’m eating a lot less than I was before treatment which is not necessarily a bad thing and still get hungry. There is very little that tastes anything like it should. Tough for a foodie that loved to cook.

Very much so.

Oh that sounds uncomfortable!

Yes. I am also using triamcinoline acetonide cream usp 0.1%. The rash is now almost gone from the chest and back but more noticeable on the sides.

Hang in there! Is your oncologist considering deescalating to just pembro after six EVP cycles? That appears likely based on your commentary.

Natera has amazing technology but very poor operations and customer service in my early experience. I almost refused to use them until my new surgeon personally assured me everything would be handled his office. He didn’t let me down. There were no problems.

Thank you and sorry for delayed response. I had switched doctors after by 2023 Turbt and my current Dr strongly advocated for Signatera. The first was before RC using the tumor from the previous surgeons turbt, second immediately after RC before chemo and then every 3 months during chemo and the following surveillance period. My medical oncologist did additional testing on the tumor before I started chemo and the plan was based on that. Sorry I don’t recall what those tests were. He’s the director of the genitourinary oncology & research program at my cancer institute . He did additional testing after Signatera became detectable this spring. I almost qualified for a new clinical trial , but had not been off chemo from last year long enough. I’ve just completed 5 of 6 cycles Evp with another Signatera and pet scan to follow. He’ll propose the revised plan based on results.

I can empathize! My rashes are pretty much everywhere except bottom of my feet and face. My team works closely with a dermatology oncologist. He prescribed triamcinoline ointment zerteck (sic) for the itch. The rash starts to flare up after the 1st treatment of both padcev and keytruda and then again after the second treatment of only padcev in the second week of every cycle. Heavy duty moisturizing with a non scented excema crème plus the prescribe ointment has kept it manageable . Odd thing is that I look like I have a tan and I peel like I have a mild sunburn. Derm has also prescribed prednisone , since 2 rash events have sent me to emergency room to rule out Stephens Johnson reaction, but luckily it has not been needed. Honestly , loss of appetite , taste and fatigue has been a much bigger issue for me. No issue with neuropathy.