What experience has anyone had with the Signatera blood test?

Hopefully it stays 0 going forward!

My results in two-month intervals are 0.25, 4.73, 0.13, 0.15, 0.17, 0.24, 0.17, and 0.00. 4.73 was two weeks after surgery and was expected. My oncologist hoped for 0.00 sooner because of 12 months of immunotherapy but better late than never.

Checkmate 274 showed this efficacy. Very encouraging!

My oncologist said that was definitely true.

That is very interesting. Your case implies nivo can keep working after completing therapy.

Natera is a fairly new blood test that measures molecules/milliliter of tumor DNA from a person's own tumor. My results in two-month intervals are 0.25, 4.73, 0.13, 0.15, 0.17, 0.24, 0.17, and 0.00. 4.73 was two weeks after surgery and was expected. My oncologist hoped for 0.00 sooner because of 12 months of immunotherapy but better late than never. This test is used to alert doctors to a problem before it shows up on scans. Anyone have experience with this test?

A silver lining is that 2025-04-11 bloodwork, showed 5.8% on eosinophils. Research has shown this increase often correlates with immunotherapy efficacy. https://pubmed.ncbi.nlm.nih.gov/38776583 https://pmc.ncbi.nlm.nih.gov/articles/PMC9078345

Unfortunately, Northstar came back at 130 today. A 4.4X increase. Hopefully, Opdivo will eradicate the MRD.

Normal stool movement this morning. So it appears it is not Opdivo colitis. That is a relief. The stool sample is no longer required as per the Mayo RN.

The CT scan came back clean. The diarrhea ended Thursday. Friday I only had two stools. Yesterday I had only one stool. So far today I have not had a stool. The PA suspects viral involvement. I never did the stool. Typically Mayo style they schedule an IV hydration session at the same time as the CT in different buildings. So I had to rush over to the main building for a CT that was delayed by 90 minutes anyway because I had to drink oral contrast. But I left the stool sample kit with the IV nurse in the other building. And by the time they did the CT that building had closed for the day. I may do the stool tomorrow if still suggested by the PA. The bloodwork came back clean except for two white blood cell types that were elevated. The PA however noted no concern with that. So it is unlikely it is colitis. I have some abdominal discomfort today similar to how it felt with chemo constipation. Hopefully, I do not have constipation now.

I now have it in writing from Billion to One that they do not charge patients when insurance does not cover Northstar Response. Just like Natera for Signatera.