What experience has anyone had with the Signatera blood test?

Posted by babab @babab, Aug 19, 2024

What experience has anyone had with the Signatera blood test. My results have been 0.13, 0.15, and now 0.17.

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jaxfl | @jaxfl | May 29 12:46pm

Today I received nivo 3. My
Liver enzymes are elevated so I will check those again next week. The elevation is more likely caused by two iron IVs in 2024-12 and 2025-02 than nivo that caused an iron deposition - mild - noted on my 2025-05-14 mri. If the enzymes do go up I will receive steroids and nivo will be on hold until the enzymes stabilize/ recede. I stopped iron supplements and vitamin c for the time being to help the liver excrete iron naturally.

They drew northstar response 3 today also. Results should be in around 2025-06-08.

annepark | @annepark | May 17 9:10am

In reply to @jowilliams1 "Great news!!" + (show)

Fabulous news !!

jowilliams1 | @jowilliams1 | May 16 4:14pm

In reply to @jaxfl "My CT and MRI yesterday came back clean fortunately." + (show)

Great news!!

jaxfl | @jaxfl | May 15 5:50pm

My CT and MRI yesterday came back clean fortunately.

jaxfl | @jaxfl | May 12 5:37pm

Excellent! Here is to long term remission!

jsbsmith | @jsbsmith | May 12 3:28pm

Hopeful update!

Happy to report that after completing four planned rounds of EV-Pembro (ending on April 24) my mom's most recent Natera Signatera test came back with no observation of any (!) of the 16 tumor-informed mutations they're looking for. We received this information via a call we scheduled with one of Natera's genetic counselors. The patient report read "Negative".

This is an improvement from my mom's March Natera Signatera test (after her first two rounds) which also read "Negative". But our oncologist learned at that time there was an observation of one of the 16 tumor-informed mutations. (To reduce the rate of false positives, Natera requires observation of two or more of the mutations for the patient report to read "Positive".)

Re-staging CT imaging confirms this progress.

We have been cleared for consolidative surgery (nephroureterectomy) on June 6, and my mom is currently recovering during a 6 week "wash out" period.

jaxfl | @jaxfl | May 11 10:19am

My 5/1 Signatera came back negative. Wait and see if the Northstar Response on 5/29 does the same. Hopefully, nivolumab is eradicating MRD, if any. CT and MRI this Wednesday 5/14.

jaxfl | @jaxfl | Apr 27 2:09pm

Hopefully it stays 0 going forward!

babab | @babab | Apr 27 12:21pm

In reply to @babab "I had Stage 2, aggressive, muscle invasive bladder cancer diagnosed in April 2023. I had 12..." + (show)

My results in two-month intervals are 0.25, 4.73, 0.13, 0.15, 0.17, 0.24, 0.17, and 0.00. 4.73 was two weeks after surgery and was expected. My oncologist hoped for 0.00 sooner because of 12 months of immunotherapy but better late than never.