What experience has anyone had with the Signatera blood test?

Interesting and encouraging update on Checkmate 274 (adjuvant nivo) with a retrospective on signatera.
https://www.annalsofoncology.org/article/S0923-7534(25)04930-0/fulltext
This week was interesting. My leg aches are less severe but still make it difficult to move around. Especially getting up and down when seated or climbing stairs. My hands and arms now have countless little white spots. The itch is still there but very slight. My hematologist recommends iron IV 3 but I am hesitant as I have concurrent IRAEs and had a deposit in May. He told me that is normal. But based on medical research it may be detrimental to ICI.

Yesterday I worked from home because my fatigue made it impossible for me to drive. Today was better but this evening I am nauseous.

@eustacia55 Tell Jeff I sympathize. The leg aches have subsided fortunately but today I have trouble staying awake.

@jaxfl I'm so sorry to hear that. For what it's worth, my Jeff feels like he must have kicked the coffee table with his left shin. He says the pain is so deep - like a bone bruise. Hang tough and know we're rooting for you.

Today was very difficult. My abdominal issues seem to have self resolved. But my leg aches, especially on the left, were so bad I barely made it into the office.

Thanks! I have five or six months left. One day at a time.

@jaxfl Hope you're feeling better soon. Immunotherapy can certainly mess with your stomach at times. I only have two months left now and I'm looking forward to ending it.

I visited urgent care yesterday as Mayo told me to check in with my PCP for my symptoms. The UC PA suspected a UTI. But obviously a RC/IC will almost always show stuff you would normally not see. So that was ambiguous. Today I felt a lot better but my stool is irregular. The bloodwork from Monday also showed no significant increase in neutrophils but a moderate increase in monocytes and an inflammation marker. So my suspicion is a low grade gastrointestinal issue. My eosinophils went down to 580 something from 690. Wait and see how this plays out.

Most oncologists only go by phase three trials and these supplements are not there yet. But there is compelling early evidence.

@jaxfl Thank you very much. We'll start researching the compounds that complement the efficacy of ICIs and see what the oncology team here has in their toolbox.