What experience has anyone had with the Signatera blood test?

Posted by babab @babab, Aug 19, 2024

What experience has anyone had with the Signatera blood test. My results have been 0.13, 0.15, and now 0.17.

Interested in more discussions like this? Go to the Bladder Cancer Support Group.

141emp | @141emp | Feb 3 2:56pm

In reply to @jaxfl "Results published yesterday 2026-02-02: negative. Praise the Lord!" + (show)

@jaxfl Thank goodness!

jaxfl | @jaxfl | Feb 3 8:01am

Results published yesterday 2026-02-02: negative. Praise the Lord!

jaxfl | @jaxfl | Feb 2 12:58pm

My 2026-01-15 signatera is still pending. Got a vague verbal statement that there is a retest. Then I was told this is uncommon but has no bearing on results. Results should be here today 2026-02-02 but nothing so far. I was also told there is a spike in tests (makes sense: huge revenue increase = more tests) and the winter storm wreaked havoc on the TX lab.

nancic | @nancic | Jan 31 7:46am

In reply to @colleenyoung "@nancic, are you currently on treatment for recurrent bladder cancer? How are you doing?" + (show)

@colleenyoung Yes. They stopped immunotherapy (Keytruda and Padcev) as it had come back to two lymph nodes and two spots on liver. I did 5 doses of radiation on lymph nodes and now I am on Gemcitabine and Cistplatin until March. We will redo scans and if it is working, I will continue. If it isn't working I will look for trails. I am trying to stay hopeful. What is your status?

Colleen Young, Connect Director | @colleenyoung | Jan 30 6:10pm

In reply to @nancic "I have had great success. It identified that my cancer had returned before it showed up..." + (show)

@nancic, are you currently on treatment for recurrent bladder cancer? How are you doing?

jaxfl | @jaxfl | Jan 26 12:57pm

Congratulations! I am awaiting my 2026-01-17 results. There is a delayed compared to last year. 2025 saw 6 to 7 days turnaround. 2025-11-20 was available on 2025-12-02. Which is 12 days. Unnecessary anxiety.

141emp | @141emp | Jan 22 6:03pm

In reply to @nancic "I have had great success. It identified that my cancer had returned before it showed up..." + (show)

@nancic , my experience has been the same. In my case,original ct scans never showed that the cancer was locally advanced outside of the bladder. I switched from a NJ community hospital after a Turbt and a second opinion. My new team of doctors at a major NY teaching hospital made that determination. I have been a Signatera “fan” ever since. When my high risk/ aggressive cancer returned this spring after being undetectable for 1 year , it again was too small to show on a CT scan. My oncologist ordered a pet scan and started chemo again achieving another full response after 4 cycles. So far so good with latest Signatera on Jan 8 still undetectable.

jaxfl | @jaxfl | Jan 21 10:17am

Nice! Keep it up!

paulhubb | @paulhubb | Jan 18 12:20am

I’ve had several Signatera tests over the past two years. All came back clean - no cancer DNA in my blood. I also have regular cystoscopies and CT scans with contrast. All are likewise clear. As long as these results continue, my doctors will continue to monitor me and consider me cancer free.