Shingrix and peripheral neuropathy

Posted by joannerhodes @joannerhodes, Feb 1, 2019

4 days after my 2nd Shingrix vaccination, I suddenly developed intense peripheral neuropathy in both feet…for the first time in my life…anyone else?

Within a week of getting Shingrix #1 in July at my local Safeway pharmacy, I too developed numbness in both feet. It is most severe in the soles/bottom of my feet. Saw my doctor about the numbness but did not think to mention the recent Shringrix shot when he asked me if there were any changes/events in my life. He drew blood and I learned that I had low levels of vitamins D3 and B12. I have been taking additional supplements for over 3 months. I was hoping the numbness might be because of the vitamin deficiencies but there has been no improvement in my feet.

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@512tr911

Within a week of getting Shingrix #1 in July at my local Safeway pharmacy, I too developed numbness in both feet. It is most severe in the soles/bottom of my feet. Saw my doctor about the numbness but did not think to mention the recent Shringrix shot when he asked me if there were any changes/events in my life. He drew blood and I learned that I had low levels of vitamins D3 and B12. I have been taking additional supplements for over 3 months. I was hoping the numbness might be because of the vitamin deficiencies but there has been no improvement in my feet.

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Hello @512tr911 — Welcome to Connect. I'm sorry to hear you developed numbness in both feet shortly after having the Shingrix vaccination. It's really hard to know what to do sometimes. I've been debating about getting the shot and had planned to get the shot but now I'm not sure. As a young adult I remember visiting the parents of a friend and the husband had shingles and you could just see the pain he was in. That thought always comes to mind for me – I definitely do not want to get the shingles. I saw an article from June 2018 that does a good job of explaining some of the benefits, risks and side effects of the Shingrix vaccination.

U.S. News Health Report – A New Shingles Vaccine: Prepare for Harsher Side Effects
https://health.usnews.com/health-care/patient-advice/articles/2018-06-15/a-new-shingles-vaccine-prepare-for-harsher-side-effects

I also have numbness in my feet from small fiber peripheral neuropathy. Do you have any pain along with the numbness in the feet?

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My legs and feet ache and are painful at night. As soon as I am on my feet all that resolves. I had the first shingles shot in ‘09 then has a mild case of shingles in 2011. Now I have had one of the Shingrix and will stop here. I know how terrible a case of shingles can be both painful and debilitating.

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@512tr911

Within a week of getting Shingrix #1 in July at my local Safeway pharmacy, I too developed numbness in both feet. It is most severe in the soles/bottom of my feet. Saw my doctor about the numbness but did not think to mention the recent Shringrix shot when he asked me if there were any changes/events in my life. He drew blood and I learned that I had low levels of vitamins D3 and B12. I have been taking additional supplements for over 3 months. I was hoping the numbness might be because of the vitamin deficiencies but there has been no improvement in my feet.

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Just to ensure I understand what you are saying: Did you think that if the numbness was from a Vitamin B deficiency that the numbness could be reversed when the deficiency was addressed? If so – are your Vitamin B levels back to normal?

To the broader audience: Regardless of the cause, can nerve damage be reversed? My understanding is that it cannot but I may be wrong.

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I have been on Vit D3 and added B12 31/2 months ago. The numbness and sleep issues feel quite static now. The medications help with my sleep needs.

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@iceblue

Just to ensure I understand what you are saying: Did you think that if the numbness was from a Vitamin B deficiency that the numbness could be reversed when the deficiency was addressed? If so – are your Vitamin B levels back to normal?

To the broader audience: Regardless of the cause, can nerve damage be reversed? My understanding is that it cannot but I may be wrong.

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@iceblue I don't know of any successful cases of nerve damage being reverse from what I've read but there seems to be some promise in a new drug treatment with pirenzepine.

Study finds drugs that can reverse nerve damage (Jan 2017)
https://www.sbrc.ca/2017/01/study-finds-drugs-that-can-reverse-nerve-damage/

There is also a recent new discussion on the topic here on Connect that you may want to join.

> Groups > Neuropathy > Anyone Heard of Pirenzepine for Small Fiber Neuropathy?
https://connect.mayoclinic.org/discussion/anyone-heard-of-pirenzepine-for-small-fiber-neuropathy/

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Aprox 2 weeks after receiving my first Shingrix shot (May 11, 2018) I started having burning & tingling in my legs ( mostly on the right side) over the next 1 1/2 years the burning and tingling has also spread to my feet and hands ( peripheral Neurapathy). Currently am taking Gabapentin for pain.
How are you currently doing?

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@jlab952

Aprox 2 weeks after receiving my first Shingrix shot (May 11, 2018) I started having burning & tingling in my legs ( mostly on the right side) over the next 1 1/2 years the burning and tingling has also spread to my feet and hands ( peripheral Neurapathy). Currently am taking Gabapentin for pain.
How are you currently doing?

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Hello @jlab952, welcome to Connect. I wasn't sure who your question was for but I'm assuming it was for @512tr911 who had the first Shingrix shot. I typed the members @ username in the message to make sure they receive an email notification for your post and question. It sounds like you had the same side effect?

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@johnbishop

Hello @jlab952, welcome to Connect. I wasn't sure who your question was for but I'm assuming it was for @512tr911 who had the first Shingrix shot. I typed the members @ username in the message to make sure they receive an email notification for your post and question. It sounds like you had the same side effect?

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This was actually meant for Joannerhodes

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@jlab952

This was actually meant for Joannerhodes

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@jlab952 — to make sure the member receives an email notification for your post just include the @ sign along with the name – like @joannerhodes. Here is the link to your post addressed to her so that when she receives this email notification all she has to do is click the View & Reply button on the email and it will take her to this post and she can click on the link below to see your post.
https://connect.mayoclinic.org/discussion/shingrix/?pg=3#comment-346687

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@johnbishop

@jlab952 — to make sure the member receives an email notification for your post just include the @ sign along with the name – like @joannerhodes. Here is the link to your post addressed to her so that when she receives this email notification all she has to do is click the View & Reply button on the email and it will take her to this post and she can click on the link below to see your post.
https://connect.mayoclinic.org/discussion/shingrix/?pg=3#comment-346687

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Thank you

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My husband has developed peripheral neuropathy affecting his feet in the last half year, and when I looked up possible causes outside of diabetes (since he is not diabetic and quite healthy with a very healthy lifestyle), I saw infectious causes including viruses like the one which causes shingles. That piece of information immediately made me line up my husband’s receiving the 2-vaccine Shingrix vaccine series with the onset of his peripheral neuropathy…tingling in his feet after the first one and now after the second one the symptoms of numbness and tingling have worsened. How is your neuropathy now? Has it lessened with the passage of time or are you having to manage it with prescriptions or therapies?

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