Seronegative spondyloarthropathy

Welcome @lairelhighlander, There are quite a few members who have posted about having seronegative spondyloarthropathy if you would like to learn what they shared. Here's the search of Connect that shows the comments - https://connect.mayoclinic.org/search/comments/.

The following NIH article mentions treatment and management options for Seronegative Spondyloarthropathy: https://www.ncbi.nlm.nih.gov/books/NBK459356/.

@dadcue, @emo, @yellowfleurs and others may have some suggestions on other medications that may work if the methotrexate is not working well to help with the symptoms. Have you talked with your doctor or rheumatologist about how you are doing with the treatment?

Yes, I was diagnosed with it a few years ago. Methotrexate takes a while to work so it’s not a quick acting drug therapy, unfortunately. Are you taking folate with it every day?

I persevered for about 4 months, but I didn’t feel completely better, so my doctor started adding other biologics with it. We tried Humira, Orencia, and Rituxan, over the years but the one I felt the best on was the newer Cosentyx infusion. If you find that you’re not significantly better soon, try asking about biologics. Good luck 😊

Took the test for TB. Came back negative.
On 4th week now. Shoulders still aren't quite right. Feel tired and can't raise arms above shoulders without pain.
Dr is keeping me on predesone due to my knee injury (messed up 3 ligaments, delaminated minuscus, burst Bakers cyst) OKd for PT. As swelling goes down, he will taper me off the steroid.
He is hoping that the major inflation of my injured knee triggered this...( Also having COVID 3x might not help).

Dr is now petitioning the insurance company to see if we can switch to a biologic. His first choice is Humara, but insurance doesn't cover it...

Thanks for all the info

@lairelhighlander there are biosimilars for Humira (Hadlima, Hyrimoz, and Cyltezo that were launched after Humira 's patent expired in 2023) that your insurance company may cover.

I was denied Rituxan but the following week was covered for Ruxience - essentially the same drug but a biosimilar that was formulary and covered under their pharmacy benefits.

Sorry you're going through this. I had Covid 5 times and my doctor is convinced that it put my immune system into overdrive. Hopefully with a biologic, you'll get some of this inflammation under control which will lead to you feeling better.

@lairelhighlander
Humira has many biosimilars approved and covered now. Your Dr. can prescribe it as generic adalimumab and discuss with your insurance which one they will provide coverage for.
Many Humira biosimilars are available: https://www.goodrx.com/humira/biosimilars

I have many symptoms of spondyloarthropathy, although my diagnosis is systemic sclerosis. I am currently on Humira/Adalimumab with oral Myfortic. After 2 bi-weekly injections with Humira, I am not much better. Although, Humira worked for me in the past. At this time, may need to consider switching to another biologic, possibly Rituximab, as it is supposed to work for both systemic sclerosis and arthritis.
If anyone had Rituximab infusions, please post your experience.

Sounds like they are gonna try me on Enbril 🤞
Just waiting for the prior pre-authorization stuff to go thru

Rx company says "Nope, ain't gonna pay". Dr appealed....same outcome.

Waiting to see what is next...

Don't know if this med would have helped, but willing to try anything. . PT is helping my damaged knee, but this "traveling" joint pain is killing me....

Sorda wish that the person denying me could have this wonder debilitating pain experience so they would know what people needing potential relief are going thru..,

@altabiznet I had it and I couldn't see any difference, so I stopped. No side effects, 'though.

@pm56

Did Ruxience work for your arthritis?
Please share your experience - response to treatment and side effects. Thank you