I found this information about Semaglutide:

Here is a bit more information on semaglutide from Mayo Clinic as well, https://www.mayoclinic.org/drugs-supplements/semaglutide-subcutaneous-route/description/drg-20406730.

@JustinMcClanahan
I am interested in group for obesity. I see the group for surgery and weight loss but not interested in that treatment. Looking for discussion on obesity medication treatments, success strategies, what has work non medicine, feeback from what otthers, etc.

I just started WEGOVY and had my first shot 4 days ago. Nothing! It is the starter dose but wondering if others have had the same reaction with first shot. I also wanted to get feedback on side affects and what to expect. I read all the warnings but most dealt with rodents and not humans for the bad side affects like Thyroid and cancers.

Hello @jc76, the group you mentioned of Bariatric Surgery & Weight Loss is for all types of weight loss, including WEGOVY - so this would still be a good group to post your discussion topic in.

Here is a search results for WEGOVY, https://connect.mayoclinic.org/search/discussions/?search=WEGOVY. As you can see there are not many discussions dedicated to this topic yet, and I do encourage you to start one in the group you mentioned.

I've been reading posts about folks struggling with GI symptoms from the GLP-1RAs for months, as I did, and someone has finally done the necessary work to demonstrate that it really helps to ramp up based on our individual side effect profiles rather than the standardized path: https://diabetesjournals.org/care/article-abstract/doi/10.2337/dc25-0690/162990/Gradual-Titration-of-Semaglutide-Results-in-Better?redirectedFrom=fulltext

Hi, @projfan - as I recall, you switched from irzepatide (Zepbound) to semaglutide (Wegovy). Are you still taking the semaglutide? Do you see the findings from this study being useful for you personally?

Yes, I'm expecting to be on semaglutide (Ozempic, not Wegovy, since Ozempic is offered as a multi-pen) forever, since I've weight-cycled my entire life, so expecting to maintain the loss strictly through behavioral changes is unrealistic. And the findings are useful to me even now: they affirm the value of using my body's reaction to the drug to guide my dosage.

I'm holding it as low as I can for maintenance (currently 15 clicks on a 1 mg pen every 6 days, which means I still have some left at the end of the 56-day pen life), and will increase it if I start putting weight back on. The low dose plus a revisiting of my drug regime means that my (many, ugh) side effects are now under control, which has let me switch my focus to beating down my migraines. In the meantime, the knee arthritis which triggered the weight loss in the first place is way better, so a win all around.

My health is trickier to manage in my 70s than it was in my 30s, but managing it gives me the life I want to live!

Wow, you should've lost at least 10 pounds by the 4th day on a .25 starter dose.😂

@wr61
My PCP stated Mayo required me to start at lowest dose and it was one shot per week. I lost no weight entire month. To be honest gained a lb. What I felt was a slight decrease in appetite for dinner. No suppression for breakfast or lunch. No reduction for snacks. I did start to have a change to bowel movents from once a day to every couple of days.

I went all the way from lowest to highest with no reduction in weight. My PCP stated I was one of those that did not react to the drug. Then after a delay starting the highest dose (wife was sick) took the 2.4 dose after 3 months of lower doses.

About 2 hours (was around 10 p.m.) felt stomach upset. Went to bed woke up in morning with nausea and vomited. Called Mayo PCP and got an afternoon appt. Vomited prior to leaving for appt. Told could not go on nausea pill due to other medication on. Given guidance on eating and having to wait for medication to leave body (which was weeks). Giving warning to drink electrolytes.

Got home around 5 p.m. and vomited. I guess unlucky one who had no reaction to drug all the way from .25 to the start of 2.4 and then the reaction to 2.4. Took about a month for me to return to normal.

My PCP asked if I would be interested in ZEPBOUND. He said had to appetite suppresors instead on one that WEGVOY had. I said no. Now months later struggling with weight. I am a very active person and was told if could keep my fitness level up could take my time losing weight.

I'm sorry you turned out to be a non-responder to semaglutide -- some people just are, unfortunately. Zepbound is a combination of another GLP-1 RA and a GIP, and some people do respond better to one drug than the other. The nausea and vomiting are common side effects, and I can definitely see them as more likely for someone who goes up sharply in dosage rather than gradually.

If you are still interested in serious weight loss, you might want to consider bariatric surgery. Nothing is the perfect answer for everyone, so this might be a better option for you than the drugs. It also has the advantage of being one-and-done.