Resolving muscle spasms on Vismodegib (Erivedge)

Posting for the benefit of others who may be suffering from cramps and muscle spasms while taking vismodegib.

Mine had been increasing in severity, disrupting my sleep 6-10 times a night besides daytime spasms. After a deep dive into the hedgehog signaling pathway exploited by this medication, I started using large quantities of electrolytes - like 10x the daily dose. (I use unsweetened drops containing sodium, magnesium, and potassium.) I also added a calcium supplement since that pathway depletes calcium as well. From what I understand, the med doesn't just diminish electrolytes, it drains them almost entirely. This has given me far greater improvement over tizanidine! I've slept two nights in a row now.

Let me know how it goes if you try it!

*Do discuss this approach with your doctor beforehand if you have any other health concerns whatsoever, and let your doctor know if you begin this approach before such discussion. Electrolytes are not to be trifled with!*