Reliable self-tests for H Pylori, and other questions
TLDR: see question 1.
Background: I had years of chronic gastritis, ulcer pain and other symptoms that led to symptomatic iron deficiency anemia, all caused by H Pylori (hereon HP), which I resolved a few years ago with antibiotics, PPIs and iron pills. I've had a few re-tests since then (including 3 breath tests and a follow-up endoscopy), which were all negative. But it is not ideal to continue using these methods to retest, for reasons I mention below.
AFAIK a lab-ordered HP test is only available three main ways:
a) requisition via a doctor (insurance covers, but doctors don't always approve, and it takes more time due to the extra appointment);
b) on-demand test via a major lab (but it's a relatively high cost per test; e.g. $200 for the breath test at Quest, which I think is the only on-demand lab option available in NY);
c) endoscopy (most invasive and time-consuming; overkill if not exhibiting long-term symptoms).
Also, although the breath test is promoted as non-invasive, the least invasive option is actually a stool/fecal test, as nothing is ingested or goes into the body. The stool test still has a relatively high rate of accuracy vs. a blood test. But it seems stool tests at major labs are not available on-demand.
This brings me to my main query:
1. It seems most if not all HP home/self-test kits on Amazon, or sold "OTC" online, are stool tests. But which are reliable/accurate? How can I be sure a kit is not fake? Anyone have any experience or advice on this? Are there alternatives to all of the aforementioned options to be aware of?
Also, I have other questions about HP I've wondered about but haven't found clear answers for, so thanks if anyone is able to help with any of these:
2. How long is the typical incubation period for HP if symptoms were to appear? Initial search says symptoms can appear 3-4 days after infection if it doesn't remain silent. Any elaboration or variation on that?
3. To what degree is an HP test sensitive to HP concentration or symptom status? For example, is someone with silent HP (or HP where symptoms haven't begun) likelier to falsely test negative than if symptomatic? Is there a demonstrable time to wait after infection (e.g. a few days) before testing to reduce the chance of a false negative?
4. If HP is present but tends to test negative, is this due to a low concentration? For example, some may see HP in a GI map but test negative for it via a breath test.
5. Is a low concentration of HP (with or without a tendency to test falsely negative) necessarily an issue if it very rarely or never causes symptoms? E.g. would taking antibiotics to nuke the gut biome be a net positive or negative in such cases?
6. Can chronic silent (asymptomatic) HP still cause metaplasia/cancer, or is chronic inflammation (gastritis, ulcers) a prerequisite? Is it possible for chronic GI inflammation to be rarely or never symptomatic yet still cause damage?
7. Can HP survive below the stomach (small intestines, colon, etc) without necessarily being in the stomach?
8. Is there any substantial evidence the body can eradicate HP naturally? Via antibodies upon infection, natural remedies, etc?
9. If reinfected, is there any downside to retaking antibiotics? (In addition to the issues of taking them at all; e.g. depletion of good gut biome). Is antibiotic resistance more likely on retaking, or is resistance unlikely if it worked the first time (as I understand there's a genetic component to antibiotic efficacy).
10. I read that HP is in its coccoid form in water but it seems unclear how infectious it is in this state. Any more detail or clarification on that?
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Hi CMX!
I was diagnosed with HP twice, in the last three years, via GI Map. I haven't truly addressed it yet, as it's lower numbers (but as per your question, what does that imply exactly?), though the second one had a virulence factor.
I'm not convinced it's causing my symptoms, but it might be. I know I should start treatment.
I am terrified to do ABX, though I'm going to try to do the newer HDDT, Amox and Vonaprazan, which supposedly has fewer side effects. One of my main complaints, constipation, seems to get agitated by every 'natural' remedy i've tried.
I also don't know if it's hormonal changes, motility, etc causing the gut/bowel issues. They're getting worse, though. As per your other question, about HP living below the gut, yeah, not sure! I've been told my constipation can be due to microbiome changes due to HP, but I think consensus is that they're still in the gut mucosa.
I also had terrible (LPR) reflux for many years, years ago, had an endoscopy and HP not detected, but there can be false negatives, and--I just don't know!
@electracat
Hi electracat, if you haven't done so already, for the LPR and any symptoms above the duodenum, I would advise doing a breath test, and for anything small intestines or below, a fecal test. I've never done a GI Map and don't know much about its reliability or usefulness in assessing related issues, but I know that a urea breath test is considered a gold standard for assessing whether H Pylori (hereon HP) has been detected at a threshold that can potentially cause issues in the stomach and above. As you are probably aware, the majority of the world has HP* but it often doesn't cause issues, but as I understand testing positive on a breath test indicates it's at a concentration in your upper GI that is not negligible. I don't know where you live but in my city (NYC) it's quite easy to book at the major labs (e.g. Quest or Labcorp) which can be referred by a doctor or self-purchased. As for anything below the stomach, it's less certain to me which test is best for that, since I tested negative on the fecal test but positive on the initial breath test and endoscopy, but I'd suggest trying a fecal test anyway since it seems it's considered more definitive than a GI Map in determining if there is a problematic HP infection.
Regarding the (false?) negative endoscopy result, false negatives may be possible since biopsies are only taken at certain locations and the bacteria may be unevenly distributed, as per this AI explanation: "The bacterial density can be reduced or the bacteria may be unevenly distributed, leading to missed detection in biopsies, so obtaining samples from multiple sites (e.g., antrum and corpus) and using additional diagnostic tests is recommended. "
This is also why a breath test is helpful - it checks all of the stomach at once instead of grabbing a sample here or there.
I don't think you should be concerned about sides from the antibiotics if you haven't tried them yet; as I understand, it's a minority who experiences noticeably bad sides. I did not experience any side effects taking antibiotics, at least at the time. Whether the periodic and easily-acquired (sometimes seemingly random) muscle/joint pain I've had since then is related, or an indirect effect due to nuking the gut biome, I'll probably never know, but in any case it has gradually improved and definitely preferable to the gastritis, ulcers, iron deficiency anemia and other GI risks from an active HP infection.
Here is what I was prescribed, in case it helps:
* 2 antibiotics for 2 weeks: amoxicillin (500mg\*2 twice/day, so 2g/day), with clarithromycin (500mg twice/day, so 1g/day) [for HP].
* PPIs for 8 weeks: omeprazole (aka Prilosec) 20mg\*2/day (so 40mg/day) for 2 weeks, then pantoprazole (aka Protonix, Pantoloc) 40mg\*2/day (so 80mg/day) for 6 weeks [for gastritis and multiple ulcers caused by HP].
* Iron ferrous gluconate (324mg\*2/day, so 648mg/day) for 3 months [for iron deficiency anemia that the HP infection eventually led to].
Since completing the above regimen, I have tested negative for HP on multiple tests including a follow-up endoscopy and breath tests, and have never had ulcer pain or gastritis reoccur. But I understand there are different HP strains (my strain was not specified; I asked the gastroenterologist but they said that's not something they test for) which can lead to different outcomes. Following a well-rated gastroenterologist's recommendation is usually a good bet.
Whether your symptoms are caused by HP or something else, it's uncertain at this stage, but since the GI Map suggests you MIGHT have HP, to me it makes sense to do more of the standard tests first, including the breath test, and if it's positive and there is no reason to suspect from other tests the symptoms may be caused by something else, then do an antibiotic regimen and see if your symptoms disappear after that.
I can't vouch for "natural" regimens I've heard about since I've never tried those, although I've seen some anecdotes that they successfully eliminated HP that way (actually tested negative after doing a natural regimen after testing positive). If it has a high rate of working, it seems enticing as it would avoid issues that some may encounter from antibiotics. But a course of antibiotics and PPIs are always the clinically recommended route, of course.
* When I say a majority of the world has HP, my guess is this is based on detectability by standard tests like the breath test, endoscopy or fecal. I wouldn't be surprised if HP existed in virtually everyone, even after antibiotics (seems almost impossible not to come across) but is only really detected by such tests when it reaches a certain threshold. This is what my GI map query partly alluded to: perhaps GI map has high sensitivity which is why it might detect low numbers of HP, whereas the number is not high enough to be detected on the other tests. Whether it can still be the cause of symptoms at such low numbers, I don't know.