Does anyone have a solution to help manage Reclast side effects?

My endocrinologist recommends stopping Tymlos for 3 months before starting the Reclast infusions (1xyr) - anyone else doing that?

I had terrible reactions to the Reclast and reported it to the FDA but nothing seems to be done about this horrible drug. I found a good Functional Medicine doctor. She started me on several supplements including mineral drops, HRT, Ozone therapy, red light therapy, etc. It was a 9 month program and very expensive but I'm much better today. I've read a lot and have watched YouTube videos about the Dexa Scan and the diagnosis or osteoporosis. I would suggest this to others. I have made the decision to NEVER take anything else for the treatment of osteoporosis. The more you learn, the more you know. I'm 73 year old and have never broken a bone.

Jaynedanco, why did you stop Prolia after five years? I’ve been on it for two years. I have an appointment with an endocrinologist in October 2025 to discuss options, Prolia holiday.

Jessicamc,
I may have missed this. What other drugs have you taken for OP. What was the sequence?

Jaynedanco, Ive not had any OP treatment other than Prolia. I really disliked taking it due to potential side effects of long term use. I was borderline between osteopenia and osteoporosis and had two spinal compression fractures. I see a dentist twice a year and recently needed a root canal. I’ve had one dental implant. Dentists, endodontists, oral surgeons are very cautious of patients who are on Prolia. Im interested in learning about options other than Prolia. I watched a short YouTube video by a Cleveland Clinic Dr who talked about trials of drugs for people who had taken Prolia 1 yr, 2 yrs. He said if on Prolia 5 yrs or more, it would be a lifetime drug.
That video was 2 yrs old so there may be newer data and better options.
Osteoporosis was the primary cause of my mother’s death and I cared for her at home and saw how much she suffered. She refused to take any OP meds. My mother’s experience and drs encouragement were my primary reasons for willingness to try Prolia. I have a hiatal hernia so oral meds are not suitable.

Gravity3, I apologize, I think I responded to you when I meant to respond to someone else.

maradeur, I hadn't heard of it but your endocrinologist may be thinking of the three months it takes for new bone to form. They may know something specific about osteoclasts effect on osteoblasts. I do know that in the first month after stopping 1-34 pth anabolics (Tymlos and Forteo) the number of osteoclasts drops more rapidly than the osteoblasts, so you'd be getting more bone from Tymlos at least during the first month.
You may have a very wise endocrinologist.

ikhender, a physician described:
"When amino-bisphosphonates (N-BPs) [Reclast] are administered IV, resulting in a high systemic exposure (unlike when taken orally, where the very low oral bioavailability results in a quite low systemic exposure), phagocytic cells other than just osteoclasts can encounter the N-BP, Up to 30% of patients can experience an APR (acute phase reaction) after their initial infusion of zoledronic acid. This APR, which starts usually about 6 hours post-infusion, and can last several days, consists of a mild fever associated with muscle and joint pains, similar to the symptoms with a bad viral infection such as the flu. And it turns out that the cause is very similar, as well. When a special category of phagocytic T-cells, called gamma-delta T-cells, encounter the zoledronic acid, they engulf it, just like an osteoclast will engulf alendronate or zoledronic bound to the bone surface. And just like an osteoclast that engulfs a N_BP undergoes apoptosis cell death, the gamma-delta T-cells that engulfs a N-BP also undergoes apoptosis. The difference is, when a gamma-delta T-cell undergoes apoptosis, it releases inflammatory cytokines, such as IL-1, IL-6, and TNF-alpha, just like when it encounters a flu virus. And these inflammatory cytokines mediate the temperature rise and myalgias."
He didn't explain about the possibility of the effect lasting a year or more. There is the 146 hour half life. But the positive feedback loop that causes a severe, systemic inflammatory response can make it self sustaining.
I think the IV steroid can break the cycle. Was it even temporarily effective for you?

I was told I had to stop it after 5 or 6 years and switch to something else or I'd be vulnerable to a break. I don't fully understand that but that's what I was told and I'm wondering now if they after this break with the reclast if I can go back on it after a year?

Before I started it, I did a visit with an orthopedic dr in FL who had an osteoporosis clinic for his opinion of Prolia and my fears of osteonecrosis or a femur break. He said he thought Prolia was a good choice and the complications were primarily with patients who took it long term without a one year pause before going back on it. He thought a one year pause after 5 to 7 years helped prevent issues.
Unfortunately I didn’t think to ask what he prescribed during the pause.,I’ve moved from FL to GA and have to find a new Dr that is up to date on osteoporosis treatments.