pT3b - What was your Decipher Score?

Posted by rlpostrp @rlpostrp, Sep 17 2:16pm

I just received my Decipher Test Score of 0.50. I am a pT3b cancer category with the following: EPE, Surgical Margins, Left Seminal Vesicle invasion (slight); and Cribriform glands.
I am interested in knowing the following from you:
1. Your original biopsy Gleason Score.
2. Your post-RP Gleason Score, if it changed on post-op surgical pathology review.
3. Your post-RP cancer category (Type 1, Type 2, etc. and any pT2 or pT3a, or pT3b, type of further-defined cancer type).
4. Your Decipher Test Score and when it was done (on biopsy tissue or post-surgical prostate tissue)?
What I am trying to do is view a range of Gleason Scores vs Decipher Test Scores vs Category/Type of cancer that your surgical pathology report said you are.
My Decipher Test Score said that I have a 1.9% chance and a 4.8% chance of metastasis at 5-years and 10-years, respectively, and a 5.4% chance of metastasis at 15-years. The second page of my report on the graphical chart has me at 4.8% risk of metastasis at 10 years ("48th percentile"). I am squarely in the "Intermediate Risk" Category, despite what are seemingly the favorably low percentages of possible metastasis. It says that such Intermediate Risk patients have moderately aggressive tumor biology.
BTW...the last risk score for me after 15 years, was "18% at RP". "RP" is apparently "Risk Adverse Pathology" per what is written below the 18%, but they don't really explain "Risk Adverse Pathology". Does that category wipe away the others because "Risk Adverse Pathology" is any of what I mention above: EPE, Surgical Margins, Left Seminal Vesicle invasion, and Cribriform glands? In other words, because I have any/all of those microscopic features, am I now at 18% risk of metastasis, and if so, "when"...at 5 years, at 10 years, at 15 years, or after 15 years, or "at ANY TIME"?
Thank you.

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Profile picture for bens1 @bens1

@rlpostrp
I have attached a copy of my Decipher test.

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Your decipher score is .25, Those other numbers on the likelihood of having a Reoccurrence within that number of years. Take a look again, and you can understand what they are saying.

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Profile picture for soli @soli

1. My pre-op Gleason score was 3+4
2. My post op Gleason score was 3+4
3. Post op cancer stage is pT3b with SVI, and w/lymphovascular and perineural invasion. Surprisingly, all margins negative!
Lymph node dissection was not performed as planned since my post-TURP prostate was so full of inflammation, it was very challenging to work with. It took so many more hours to complete the surgery that they were not to able perform the bilateral lymph node dissection as planned. They only managed to do one which was negative.
4. My urologist ordered Decipher test yesterday, and PSA test 2 months after the surgery which took place on September 2nd. I have a follow-up meeting with my urolgist on November 10th. I believe the major decison at that time is if and when to start additional treatment: right a way, or wait for PSA to rise.

GPS score before surgery was 47, which suggests a very aggressive biology of my porstate cancer.

I could be wrong (and I hope I am wrong) but my Decipher test will probably show a very high risk disease that will require additional treatment at some point, maybe sooner than later.

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Soli, thanks for the update about your case.

Please keep us posted since there are couple of us at this very moment that deal with T3 issues and wonder what to do next.

Thanks so much in advance and wishing you 0.01 PSA in two months 🍀🍀🍀🧚‍♀️ !

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Sorry everybody - my husband has a record number of 1 !!! 😜 You all are like soooooo far behind, no way you can top that ( one has to laugh or ...) ! 🏆🥇🦸

One tiny EPE (0.2 mm) and "iffy"at that, could be that it just looks like that. PNI found, but inside the gland. One tiny part of "iffy" margin which was burned and so they do not know if it is positive or negative, but no cancer behind the line (outside) - so yeah, situation can go from great to terrible, depending of how you look at the findings.

He is T3a.

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Profile picture for surftohealth88 @surftohealth88

Soli, thanks for the update about your case.

Please keep us posted since there are couple of us at this very moment that deal with T3 issues and wonder what to do next.

Thanks so much in advance and wishing you 0.01 PSA in two months 🍀🍀🍀🧚‍♀️ !

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Thank you @surftohealth88 for your best wishes. I also with your husband the best possible outcome.

I will definitely keep you posted of next steps as my recovery progresses.

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