PRP (platelet rich plasma) injection?

Posted by lgerkin @lgerkin, Mar 3, 2021

Has anyone had PRP injections? I have upper hamstring tendonitis and recently had a prolotherapy injection, which hasn't seemed to help, so I'm looking at other options. I know they're expensive and not covered by insurance but if the success rate is high, it's something I might consider. Thanks!

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Profile picture for helenrose @helenrose

Thanks for letting me know. I have a consult this week.

Glad it was so successful for you.

Helen

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@helenrose My doctor is going to have me do an MRI of my tendon (where IT band is I believe). Have to set that up. Yes here it costs about $1,000.

Helen

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It appears as if there's a lot of trial-and-error going on, and that the devil may be in the details.

A couple of useful papers:
-- https://pubmed.ncbi.nlm.nih.gov/38021947/ : "There is level I evidence available supporting its efficacy in the treatment of osteoarthritis (OA), epicondylitis, bursitis, compressive neuropathy, plantar fasciitis, muscular injuries and osteochondral lesions. Most published research with regards to PRP has been focused on knee OA (limited research in shoulder, elbow, and foot and ankle OA), lateral epicondylitis and carpal tunnel syndrome, whereas spinal and hand conditions have limited research available. Tendinopathies and partial tendon tears have conflicting evidence available, with level I evidence supporting PRP's use in rotator cuff tendinopathies and tears, with contradictory level I evidence discouraging its use in patella and Achilles tendinopathies and tears. The available evidence regarding the use of PRP continues to produce conflicting results, but despite this, there is an ongoing increase in the popularity and use of PRP in patients with musculoskeletal conditions."
-- https://pubmed.ncbi.nlm.nih.gov/39124838/: "Results: Out of 75 RCTs involving 5726 patients, the review identified significant variability in PRP preparation methods and application techniques, including differences in centrifugation protocols and platelet concentration levels. A new evidence-based scoring system, the William-Eqram Scoring System for PRP Quality Reporting (WESS-PQR), was proposed to address these inconsistencies. Correlation analysis revealed a strong positive correlation (r = 0.79) between proper temperature control during preparation and PRP efficacy. Initial platelet count assessment showed a moderate positive correlation (r = 0.57) with efficacy. Conclusions: Standardized PRP preparation protocols and robust regulatory frameworks are urgently needed to ensure the safety and efficacy of PRP treatments. The proposed WESS-PQR scoring system can serve as a valuable tool for clinicians and researchers, promoting consistency and reliability in PRP applications. "

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Profile picture for projfan @projfan

It appears as if there's a lot of trial-and-error going on, and that the devil may be in the details.

A couple of useful papers:
-- https://pubmed.ncbi.nlm.nih.gov/38021947/ : "There is level I evidence available supporting its efficacy in the treatment of osteoarthritis (OA), epicondylitis, bursitis, compressive neuropathy, plantar fasciitis, muscular injuries and osteochondral lesions. Most published research with regards to PRP has been focused on knee OA (limited research in shoulder, elbow, and foot and ankle OA), lateral epicondylitis and carpal tunnel syndrome, whereas spinal and hand conditions have limited research available. Tendinopathies and partial tendon tears have conflicting evidence available, with level I evidence supporting PRP's use in rotator cuff tendinopathies and tears, with contradictory level I evidence discouraging its use in patella and Achilles tendinopathies and tears. The available evidence regarding the use of PRP continues to produce conflicting results, but despite this, there is an ongoing increase in the popularity and use of PRP in patients with musculoskeletal conditions."
-- https://pubmed.ncbi.nlm.nih.gov/39124838/: "Results: Out of 75 RCTs involving 5726 patients, the review identified significant variability in PRP preparation methods and application techniques, including differences in centrifugation protocols and platelet concentration levels. A new evidence-based scoring system, the William-Eqram Scoring System for PRP Quality Reporting (WESS-PQR), was proposed to address these inconsistencies. Correlation analysis revealed a strong positive correlation (r = 0.79) between proper temperature control during preparation and PRP efficacy. Initial platelet count assessment showed a moderate positive correlation (r = 0.57) with efficacy. Conclusions: Standardized PRP preparation protocols and robust regulatory frameworks are urgently needed to ensure the safety and efficacy of PRP treatments. The proposed WESS-PQR scoring system can serve as a valuable tool for clinicians and researchers, promoting consistency and reliability in PRP applications. "

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@projfan Thanks so much for this; "information is power."

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Profile picture for Justin McClanahan, Moderator @JustinMcClanahan

Hi @helenrose,

I combined your discussion with the following discussion:

"PRP (platelet rich plasma) injection?"
- https://connect.mayoclinic.org/discussion/prp-platelet-rich-plasma-injection/

While it is a lengthy discussion, you can read through many members' experiences and they will also see yours as well.

@helenrose, are you experiencing pain with your bursitis and looking to get some relief with PRP vs. surgical options?

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@JustinMcClanahan
Yes, every year. Due to have one in mid january

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I just received my fourth PRP injection. Have experience notable relief in my knee. Dose and number of spins seem to be in the equation for positive results.

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Profile picture for rosema4 @rosema4

I just received my fourth PRP injection. Have experience notable relief in my knee. Dose and number of spins seem to be in the equation for positive results.

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@rosema4

Are you eventually going to get your knee replaced? PRP helps but is a band aid to provide some relief, and to help better time TKR surgery.

I had both knees replaced in 2022. I'm 71 now and the pain relief was instant. Rehab is challenging but certainly doable.

I wish you the best.

Joe

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