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Prolia infusion and BE flare afterwards
Has there been research or discussion about prolia infusions for osteoporosis and their propensity to reduce one’s immune response that leads to a bronchiectasis flare? Is there a protocol to prevent/ameliorate this eg the same way that those with knee replacements take antibiotics prior to a dental cleaning?
Looking back at my history since starting the prolia treatment I do seem to have a flare that often then requires antibiotics.
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I just did a search for infections related to Prolia and it looks like there is a small risk of increased serious infections. SAEI=Serious adverse events of infection.
A Canadian review of studies in 2021 by Catton concluded: "Conclusion: Denosumab-treated patients with low bone mineral density have slightly increased incidence of SAEI compared with placebo, but not when compared with bisphosphonates. Application of these results requires consideration of the entire body of data available regarding denosumab safety."
There's a more recent study from Taiwan also indicating a small increase in infections.
I didn't see any with just bronchiectasis. Given the info, I'd discuss it with your doc to decide risk/benefit. Good luck to you
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1 ReactionIs anyone doing the Reclast infusions, and if so have you had any increase in exacerbations with it?
I was diagnosed with bronchiectasis in 2012. Started Prolia in 2023. So far, I have not had any serious infections. If you have not received flu, RSV and Covid boosters, discuss with your Dr.
I took a Mediterranean cruise six months before starting Prolia and caught RSV before the vax was available. I was hospitalized for 7 days. When the RSV vax became available 3 months later I took it.
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