Prolia and its side effects.

@neverretire I see an endocrinologist. After taking a complete history and reviewing my chart that shows a sacral fracture in 2023 the endocrinologist recommended Evenity for 12 months (I go once a month to an infusion center for two injections). My endocrinologist said that I was doing everything I could do with diet and exercise for osteoporosis but the fracture changed that for me. So, just as @windyshores posted here Evenity is often prescribed for people like me who have had a fracture.

I suggest that you ask your internal medicine/primary care provider to refer you to an endocrinologist (or rheumatologist). These specialities are well versed and trained in treating osteoporosis. I'm not thrilled with getting those Evenity injections every month but if the medication prevents future fractures I am and will be thankful that I did what was recommended.

@neverretire What will you do next?

@gently I wonder if, after dealing with rebound with Reclast or Fosamax, it is possible to get on a bone builder. Evenity is so new but maybe that is possible. I don't know if doctors even know.

My friend's doctor put her on Tymlos after Prolia. Leder and McCormick both say this sequence is not effective. What is the answer for those on Prolia who want to get off, beyond addressing rebound?

The trouble with Prolia is the "resevoir" of preosteoclasts. You need the strongest medication to stop them. Zoledronate has the best mechanisms.
There is evidence that teriparatide therapy is more effective with Prolia. The HD Data trial evidenced that Prolia is able to "fully" inhibit the increased osteclast activity of Forteo It's possible to begin Tymlos or Forteo before the six months of Prolia is exhausted, You'd still need the antiosteoclast-antiresorptive at the end of six months. Would you want to stop the pth with the initiation of bisphosphonates. Maybe not.
I'm not happy with the idea of taking two of these pharmaceuticals concomitantly. Too many averse effects with just one.

After being diagnosed with Celiac Disease in 2019, within a short period of time I was thrown into osteoporosis. It was suggested I start Prolia injections. I started Prolia in December 2021 without any literature or information on the drug (shame on me for not doing my due diligence and relying on my doctor’s request).
It was billed as an infusion when it was merely a shot in the arm and sent on my merry way. When I saw the $6000 price tag and my $300 copay I refused to go back. In April 2023, I fractured my T12 getting into bed. I was then told by a spine doctor that I needed to do something or my life would be further fractures.
So, back on Prolia. The side affects are horrendous with having about 8 on the list. I told my husband I feel like I’m injecting “death.”
What is the answer? I definitely do not want to continue this drug.

After being diagnosed with Celiac Disease in 2019, within a short period of time I was thrown into osteoporosis. It was suggested I start Prolia injections. I started Prolia in December 2021 without any literature or information on the drug (shame on me for not doing my due diligence and relying on my doctor’s request).
It was billed as an infusion when it was merely a shot in the arm and sent on my merry way. When I saw the $6000 price tag and my $300 copay I refused to go back. In April 2023, I fractured my T12 getting into bed. I was then told by a spine doctor that I needed to do something or my life would be further fractures.
So, back on Prolia. The side affects are horrendous with having about 8 on the list. I told my husband I feel like I’m injecting “death.”
What is the answer? I definitely do not want to continue this drug.

Neverretire, it is too much and hard to digest, but what will you do.
We collect symptoms and would add your eight if you get in a talkative mood.

After being diagnosed with Celiac Disease in 2019, within a short period of time I was thrown into osteoporosis. It was suggested I start Prolia injections. I started Prolia in December 2021 without any literature or information on the drug (shame on me for not doing my due diligence and relying on my doctor’s request).
It was billed as an infusion when it was merely a shot in the arm and sent on my merry way. When I saw the $6000 price tag and my $300 copay I refused to go back. In April 2023, I fractured my T12 getting into bed. I was then told by a spine doctor that I needed to do something or my life would be further fractures.
So, back on Prolia. The side affects are horrendous with having about 8 on the list. I told my husband I feel like I’m injecting “death.”
What is the answer? I definitely do not want to continue this drug.

Hello Ladies - this has been my journey so far, and just needing to VENT!. I have been under the care of an endocrinologist for 10 years because I have a hereditary history of Osteo . Took Fosamax for 5 years and then a break from meds with my T-scores holding. Ended up breaking my wrist last Sept., and Bone density showed my T-scores getting worse.
Dr. said needed to get on something ASAP. My recommended choices were Evenity (monthly injections) or Forteo/Tymlos (daily self admin injections. I chose Evenity and have had 7 injections. Will be getting a Calcium blood test which hopefully shows some improvement. My doctor is recommending that I take Prolia after the Evenity.
I honestly feel our doctors are doing their best, but I don't think there is any one right way about which meds and in what order to take them. Unfortunately there has not been enough long-term research to know with certainty what works best.
I wish everyone a good and safe journey.

After being diagnosed with Celiac Disease in 2019, within a short period of time I was thrown into osteoporosis. It was suggested I start Prolia injections. I started Prolia in December 2021 without any literature or information on the drug (shame on me for not doing my due diligence and relying on my doctor’s request).
It was billed as an infusion when it was merely a shot in the arm and sent on my merry way. When I saw the $6000 price tag and my $300 copay I refused to go back. In April 2023, I fractured my T12 getting into bed. I was then told by a spine doctor that I needed to do something or my life would be further fractures.
So, back on Prolia. The side affects are horrendous with having about 8 on the list. I told my husband I feel like I’m injecting “death.”
What is the answer? I definitely do not want to continue this drug.