Probability of passing on Von Willebrand's

Hello @abbiem Von Willebrand’s is primarily an inherited disease caused by genetic changes that are almost always inherited (passed down) from a parent to a child.

The Center for Disease Control and Prevention has some very informative articles regarding Von Willebrand’s disease.
I’ve posted two links below. The first discusses VWD and facts about the disease.
The second article explains the genetics behind inheritance of the disease.

This is an excerpt from the first article. (The link is directly below the excerpt)

“Most people who have VWD are born with it. It almost always is inherited, or passed down, from a parent to a child. VWD can be passed down from either the mother or the father, or both, to the child.

While rare, it is possible for a person to get VWD without a family history of the disease. This can happen if a spontaneous mutation occurs. That means there has been a change in the person’s gene. Whether a child receives the affected gene from a parent or as a result of a mutation, once the child has it, the child can later pass it along to his or her children.

Also, it is rare, but possible, for a person to get or acquire VWD (they didn’t receive the affected gene from their parent or as a result of a mutation) later in life because of an underlying medical condition. This can happen when a person’s own immune system (which controls the body’s ability to fight germs and sickness) destroys his or her VWF, often as a result of the use of a medication or as a result of another disease. If VWD is acquired in this way, it cannot be passed along to any children.”
https://www.cdc.gov/ncbddd/vwd/facts.html
On inheriting the disease:
How von Willebrand Disease Is Inherited
https://www.cdc.gov/ncbddd/vwd/inherited.html
Do you have VWD or know of a family member who has it?

my daughter-in law has vwd, her vwf is 63, ristoceton cofactor 44, Factor V111 cloting activity 54, factorV111 chromogenic 40, vwf multimer study normal, genetic study did not find any specific mutation, since this disease is autosomal dominant, anychild she give birth to will have 50% chance inherit it. anybody has suggestions?

@jin762, I moved your question to this existing discussion:
- What is the probability of passing on Von Willebrand's https://connect.mayoclinic.org/discussion/probability-of-passing-on-von-willebrands/

I encourage you to read the well-informed reply by @loribmt to @abbiem.

@jin762, are your son and his partner considering to start a family?

Hello!
I am from Brazil! I have read there is a 50% of probability to pass on VW for our child. But in my family, My nephew has got the diagnosis after frequent bleeding nose many and my sister hasn't got it so far. My eldest sister has Von Willebrand but her son doesnt...I have just got my results positive this week...but my results were negative a year ago...I am used to having blood blisters on the tongue, mouth, depending on what I eat...many bruises. ..I will take my son to a hemathologist tomorrow...

@loribmt
Good evening!
if we are born with the desease...how my results were negative last year and turned into positive in one year. Is that possible? My father had aplastic anemia and passed away...he had never been tested in hospital for VWD. But he probably had it too. I have got 2 siblings, and two of us has been diagnosed with VWD, what is the chance of my youngest sister has the factor but with no symptoms and passed for her son...The symptons may come up in any time in life, or she might be free from desease?

Hi @fabignk, From what I understand, while VWD is generally a genetically inherited disease, it can (rarely) also be a secondary disease that ‘just happens’. Genetic’s can be complicated when it comes to passing along a disease through children.

This reply that I wrote to another member regarding Von Willebrand Disease, (VWD) contains links to a couple of good articles that might be helpful for you to read through.
Though the best answers would come from your and your family’s hematologist . https://connect.mayoclinic.org/comment/887317/

I’m sure this is a time of high anxiety for you and your sister regarding both of your sons. It was great news that your nephew isn’t a carrier of the gene. You mentioned in another comment that you were going to be taking your son to see a hematologist to have him tested. What was learned from that appointment? Is he free from the disease?