Pre-diabetes and SSRI (zoloft)

Posted by morgrob @morgrob, Mar 15 12:55pm

I have a question about being in the pre-diabetic range, but then after a year of taking Zoloft, my A1C jumped to 6.5% from ~ 5.9%. While I am sure my lifestyle and diet are also to blame, my question stems from could an A1C be inflated due to the SSRI, and that if one were to go off it, and do nothing else, A1C could be back in the pre-diabetic range? I am just trying to rationalize what the contribution of the SRRI could be and since they are known to cause issues with regulating blood sugar, could the A1C be artificially high induced by the Zoloft, or should someone still be able to produce enough insulin to combat that? Just seeking some clarity.

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@morgrob the answer to your question is maybe (sorry). When you have any stage or type of diabetes it can be affected by so many things. On the flip side diabetes affects everything else that you have going on. It is a two way street. When it comes to medications it comes down to trusting the prescribing provider. Your providers need to know your history and you need to keep your provider informed of any changes &/or concerns you might have. When you have more than one condition and provider make sure everyone collaborates and are on the same page. Who is treating your pre-diabetes? Who prescribes your Zoloft?

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Did your endrogolist tell you SSRI affect the glucose levels

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They are both monitored by my primary care doctor. There are several published peer reviewed articles about SSRI and glucose levels increasing with some SSRI and some decreasing with SSRI, or at least that is harder to control blood sugar levels on SSRI.

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Never heard of Zolof being used for diabetes. I found a Google on it:

This medication is used to treat certain mental/mood disorders (such as depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder).

https://www.webmd.com/drugs/2/drug-35/zoloft-oral/details
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I guess maybe I was not clear. Let me rephrase. My blood tests have been recently in the pre-diabetic range < 6.5. I started Zoloft for anxiety last year. Now, my blood test has been at 6.5% for A1C. This is monitored by my PCP. My question is, if anyone knows, if Zoloft can have an affect on blood sugar regulation either inhibiting or enhancing some metabolic pathway, either in the liver or pancreas, could the 6.5% be a false positive for T2D? The Zoloft is not taken to do anything purposefully for my blood sugar. The issues with blood sugar are a side effect of taking the Zoloft to treat anxiety for me.

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