Post viral syndrome peripheral nerve hyperexcitability

Posted by josh701 @josh701, Apr 6, 2025

Hi everyone,
I’m a 36-year-old navigating recovery from what’s been described as post-viral small fiber involvement and motor nerve hyperexcitability.

How It Began:

It started after a viral illness in August 2024, during a time when my whole family had upper respiratory symptoms.

I developed fever, diffuse headache, and left-sided temple pain, which later localized and became persistent.

By January 2025, I began to experience:

Burning sensations

Pins and needles

Odd wet or sunburn-like skin feelings

Muscle fasciculations (twitches) across my body

Migratory muscle pain and intermittent joint discomfort

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Workup So Far:

MRI of brain and cervical spine: Normal

Autoimmune workup: Negative

Skin biopsy: Normal epidermal nerve fiber density

Nerve conduction studies & EMG (lower extremities): Normal

CBC, CMP, CRP, ESR, CK, aldolase, B12: All normal

No evidence of large fiber neuropathy or motor neuron disease

No clinical weakness or atrophy

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Current Working Diagnosis:

Post-viral small fiber sensitization

Motor nerve hyperexcitability (likely benign fasciculation syndrome or similar)

Significant health anxiety, especially due to my medical background and profession

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What’s Helping Me:

Gabapentin (600 mg at night)

Supplements:

Magnesium glycinate

CoQ10

Alpha-lipoic acid (ALA)

Omega-3

Curcumin

B-complex

Vitamin D3 + K2

Ashwagandha, glycine, apigenin (for calming and sleep)

Exercise: Strength remains intact and working out reinforces my confidence

Mind-body tools:

Headspace and Curable app

Weekly visits with a psychologist

Gratitude journaling

Somatic calming techniques (breathing, grounding, mantra work)

New mantra I use daily:

> “One in a million. I am strong. This will pass.”

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Biggest Lessons:

Even with scary symptoms like widespread twitching or burning, the body can be in a state of hyperawareness, not disease.

I’ve learned the importance of regulating fear and stress to support nervous system healing.

Benign doesn’t mean painless—but it does mean hopeful.

Working with a neurologist, psychologist, and staying grounded in scientific reasoning has helped me reclaim my peace.

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Happy to connect with anyone navigating something similar. You're not alone—and your body is capable of calming, rewiring, and healing.

Interested in more discussions like this? Go to the Neuropathy Support Group.

I also have increasing swelling edema around my ankles behind my ankles in front of my ankles and all on my shit for no real reason, but I have had burning and redness and tingling for a long time only getting worse spread to my other foot. No doctor can give me the answer for my edema except to say I I don’t move enough, but I move as much as I can and I still walk relatively a lot so I’m wondering if anyone has something like that as well. The swelling that causes a lot of discomfort

REPLY
Profile picture for SusanEllen66 @SusanEllen66

Please check out Functional Neurological Disorder FND.

It’s what I have. There are no tests that show it because it’s not a physical condition.
It is described as a “software” issue between your brain and body.
Stressful times make it so much worse. I get tremors, my speech changes, my muscles will “freeze” in place.
They send you for physical therapy, and a psychologist to ease the symptoms.

I was diagnosed by a neurologist who specializes in Movement Disorders.

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@SusanEllen66

Hi Susan I feel like what I am expericing does have some overlap with FND. Thank you for the suggestion.

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Profile picture for dlydailyhope @dlydailyhope

@josh701
Did you ever have Covid? Did you ever have Chickenpox or Shingles? Did you ever have exposure to the Epstein Barr (mononucleosis) or Herpes virus? It would be good to see if you could get testing for viruses since some viruses can lay dormant in your nervous system and get aggravated and reactivated by stress, illness or hormone changes. Some viruses are in your body for life and it then is important to find ways to keep them dormant and not reactivated since this causes neurological symptoms.

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Hello @dlydailyhope

I just stumbled over your post from April last year.

I have been struggling with neuropathy for years. Influenza last January caused major increase of symptoms.

I have tested blood for Epstein Barr, result showed extreme high antibodies over 700 which suggests I have recurring viral reactivation.

Any ideas how to prevent viruses from reactivating and keeping them dormant, as you have suggested?

Any input/experience appreciated 🙂

REPLY

Thank you for posting this. I have a lot of the same symptoms with similar tests and thrown under the fibromyalgia group. All the best.

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