Anyone had Pluvicto at age 90+? How were the side effects?

I sure Would not want to be on Zytiga at 90. That drug really is hard on the body. It caused me to have high blood pressure, Many hot flashes and multiple Afib Events. It’s pretty hard on the heart.

I’m 78 and was on it for 2 1/2 years, I was only undetectable one month. I switched to Nubeqa And it has kept me undetectable for the last 25 months after 16 years of prostate cancer. I know a lot of people over at ancan.org that are using Nubeqa Instead of the other drugs because it has the least side effects and doesn’t pass the blood brain barrier and cause brain fog. Many of the people over there in their 70s and 80s are just on Nubeqa Alone since it works so well, even with testosterone present.

You might talk to your doctor about other drugs. Switching out Zytiga for Nubeqa Could make life a lot better. If he does that, prednisone must be tapered off over a period of months or it will cause extreme fatigue if you stop it too quickly. Pluvicto can have some serious side effects, but it is easier than chemo says the people I know that I’ve done both.

The most common side effects of Pluvicto (lutetium-177) include fatigue, dry mouth, nausea, and decreased blood cell counts.

Dry eyes and dry mouth are commonly mentioned because Pluvicto goes after anything that expresses PSMA - not only prostate cancers, but also saliva and tears (and blood, liver, spleen, pancreas, ganglia, as well as the kidneys, ureters and the bladder (as the body tries to quickly excrete the radioligand that was injected)).

@tneal4433, age is a number. While age is certainly a factor to consider, not everyone is the same. Were you able to discuss the side effects of Pluvicto and how they may affect your father relevant to his health status as well as age? Also to be considered are personal preferences and desire to continue with treatment of not.

What did your father, family and care team decide? How is you dad doing?

We actually just did his psma pet scan last Wed and go to the doctor Monday at 2 to discuss Pluvicto and then if dad decides to do that we meet with the radiologist Tuesday. Dads in a lot of pain in his hip area and is ready to be done with it all he says. He has been prescribed Oxy which helps but he doesn’t take evey six hours as prescribed because of the addiction possibility which I’ve explained even that at age 89 (90) in Jan) is ok that quality of life is what we should strive for because of the pain he can’t do much of anything. Thanks so much for checking in.

At age 91 I've had 3 of the prescribed 6 Pluvicto treatments. PSA dropped from 8.9 to 2.2 after the first two treatments. (PSA after the third treatment is not scheduled until next month) The most prominent side effect is a dry mouth which dissipates slowly after each treatment. Since the metastatic cancer was diagnosed and ADT started two years ago , fatigue and loss of strength has been issue, which I offset partially with exercise. Other than a biopsy I've had no direct no interventions to my prostate. As Coleen notes everyone is different. I'm still uncertain whether I'll benefit in the long run from Pluvicto, but I'll keep doing it as l can tolerate what have been fairly mild symptoms so far.

I am eighty three, and i've had the six required pluvicto injections. Minimal side effects until after the 6th infusion. Since the cancer matasticd to the lymph nodes I developed lymphedema in my legs. If your cancer didn't spread to the nodes I don't think you'd have this problem. Otherwise side effects are as advertised, dry mouth, low red and white blood count. Meanwhile my psa went from 8+ to undetectable. Psma pet scan showed no matastic cancer. First time in 25 years I've been cancer free. How long will it last, hopefully til some new treatment is discovered.

Thanks @tigriopus David for chiming in to share with @tneal4433. It helps to hear from someone in the same age group.

Thank you so much for this information. It certainly helps to hear from someone who has been through it.

New to the blog:

Short version:

Dad will 91 in April. Diagnosed with prostrate cancer Dec22. PSA was 2600. Cancer was in spinal cord, upper pelvis, lungs and jawbone. Started on Xgevia, Zoledex and xstandi for 3yrs. Has had some spot radiation treatment for minor flair ups. Past Dec cancer started to become castrate. Doc’s recommend Plivicto. Had first treatment today. Given 50-50 chance that this treatment will actually help. Dad lives alone. Refuses to move from his house to live with me. Has high blood pressure and high cholesterol. But otherwise ok. My concern was his PSA .50 already but the cancer is still growing. In addition, the side effect of losing weight. He already is 126lbs wet and fluctuates between 117-126lbs. We have been battling his weight loss for 3 yrs now. Doesn’t drink enough water and eats very unhealthy. Ie. box meals.

Thanks for some insight on Plivicto. At this anything is worth a try.

My dad has now turned 90 and has been on zytiga/lupron for one year and two months but psa is now going up so we have the PSMA scan scheduled for March 6 and a consult about Pluvicto March 11. My dad has maintained his weight of 147 the whole time and has debilitating pain in his hip area which he had five radiation treatments that didn't help the pain. He started out with PSA of 5600 and got down to 90 before it went up to 270 a week ago.
This has metastasized to his bones from head, spine, ribs femur, hip etc. I'm not sure if dad will go through the Pluvicto or not. Mom is still living and they have heard they may have to stay away from each other for a bit right after the injection. Can you give me some insight or what has to happen right after the treatment. My dad is getting tired of trying but said he would at least talk to the doctor about it. Even though they are 90 it's still hard to watch them suffer. I would appreciate any information you can give me before our consultation. Good luck today, I'll say a prayer that all goes well.