I am an 84 male with inherited PKD2. My creatinine hovers around 200. And my kidney functioning hovers around 25%. I am experiencing unusual fatigue Do feel pain in back at kidney levels. Buy so tired it is hard to walk far or do chores. Wondering if fatigue is a typical symptom at this level of the kidney disease.? Or should I be looking for some other cause. When does kidney functioning lead to debilitating loss of energy ?