Anyone used PEA for neuropathy pain relief?

Posted by stellarg @stellarg, Nov 11, 2024

I tried the first 300 mg dose last evening but was awakened about 6 hrs. later with severe itching on both lower legs and ankle areas...I don't know if cause/effect applies. Has anyone else experienced similar PEA side effect?

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Profile picture for jchet @jchet

Be Careful. I ordered PEA from Amazon, but will return it as I found out that you should not take it if you’re on Eliquis (blood thinner).

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Where did you read about PEA and eliquis?I am on eliquis but wanted to give PEA a try.

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In Italy, neuropathy is treated with Lipoic Acid & PEA. Has anyone tried PEA or the above combination in the USA?
Jim in SC

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Profile picture for jeaiken @jeaiken

In Italy, neuropathy is treated with Lipoic Acid & PEA. Has anyone tried PEA or the above combination in the USA?
Jim in SC

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@jeaiken what is PEA

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Profile picture for jeaiken @jeaiken

In Italy, neuropathy is treated with Lipoic Acid & PEA. Has anyone tried PEA or the above combination in the USA?
Jim in SC

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Hi Jim @jeaiken, We merged your post with an existing discussion so that you could meet other members who have mentioned using Palmitoylethanolamide (PEA) for pain. If you click the link below it will take you to the beginning of the discussion where you can learn what others have shared.
-- PEA for pain relief?: https://connect.mayoclinic.org/discussion/pea-for-pain-relief/

@1kay2 and Jim, Here is some additional information on PEA that might be helpful:
-- Palmitoylethanolamide (Pea) - Uses, Side Effects, and More:
https://www.webmd.com/vitamins/ai/ingredientmono-1596/palmitoylethanolamide-pea

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Profile picture for jeaiken @jeaiken

In Italy, neuropathy is treated with Lipoic Acid & PEA. Has anyone tried PEA or the above combination in the USA?
Jim in SC

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@jeaiken
I have no noticeable short term effect from R-ALA and PEA. Possibly slight effect longer term (over 3 wks+). I think it is good to mention dosages when discussing any treatments (since YMMV), so, R-ALA 100-300mg/day and PEA 300-1200mg/day.

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