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Painful Kevzara Injection

Posted by kwahearn @kwahearn, Jul 13, 2025

I'm a 73-year-old female in otherwise good health, but was diagnosed with PMR in August 2024. After tapering down from 20 mg/day Prednisone to zero, then taking methotrexate (8- 2.5 tablets weekly), I had my first Kevzara injection last week. I was pleased that the self-injection pen needle did not hurt very much, but I was shocked at how painful the medicine was as it entered the subcutaneous layer of my abdomen. (I had set it out from the refrigerator for 2 hours prior to injection.) Has anyone else had the same pain?

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caroljeand | @caroljeand | Jan 23 11:09am
In reply to @mikeydee "@stonewheel I do the same ... "I pinched an inch of belly fat, 4 inches away..." + (show)
Profile picture for mikeydee @mikeydee

@stonewheel I do the same ... "I pinched an inch of belly fat, 4 inches away from my navel and injected."I feel localized pain as the kevzara enters my body but it goes away very quickly after the injection... No other issues with the injection... I think the secret is to inject into your body fat...

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@mikeydee
Wish I had more body fat on my legs than on my stomach.
I find it awkward to try to inject my stomach so I do my best on my skinny thighs.
Wish this med came in a pill!

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stonewheel | @stonewheel | Jan 23 6:02pm
In reply to @mikeydee "@stonewheel I do the same ... "I pinched an inch of belly fat, 4 inches away..." + (show)
Profile picture for mikeydee @mikeydee

@stonewheel I do the same ... "I pinched an inch of belly fat, 4 inches away from my navel and injected."I feel localized pain as the kevzara enters my body but it goes away very quickly after the injection... No other issues with the injection... I think the secret is to inject into your body fat...

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@mikeydee yes and close to body temperature

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