Pain control irritable bowel

@winweb, I have not used those medications however these links present the role vitamin B1 plays in the gut and it may help you. . Note that magnesium is needed to activate B1 (thiamine). Activated thiamine is needed to activate B6 so you see the B vitamins work better together. Standing in the way of normal thiamine intake are anti thiamine factors that diminish or destroy thiamine. Always consult your health care provider before using any supplement.
http://stuttersense.blogspot.com/2014/08/these-factors-reduce-your-thiamine.html
https://www.eonutrition.co.uk/post/when-sibo-ibs-constipation-are-just-unrecognized-thiamine-deficiency
https://www.healthrising.org/blog/2021/06/02/fibromyalgia-chronic-fatigue-syndrome-benefit-high-dose-thiamine/
https://www.eonutrition.co.uk/post/mega-dose-thiamine-beyond-addressing-deficiency

Cymbalta has horrible side effects and trying to get off it is H..
Yet seems to be the only thing that reduces my abdominal pain
I have tried low FODMAP, registered dietician, reducing amines, ENT , autoimmune Dr , neurologist , accupunture , nothing helped ..wish I could find a dr that calls back that sticks with me that cares they all have way too many patients and don’t see to be good on follow up any have an anazing GI in the St. Louis area please share !!!!