Oxaliplatin is no walk in the park, advice for CAPOX regimen?

I hope your doctor will listen to you and closely monitor your side effects. I was told by my oncologist that Capox was the “easier” chemo tx, but I had all the symptoms - neuropathy, cold sensitivity, severe muscle contractions in jaw, hands and legs, dizziness, difficulty focusing eyes, and brain fog along with more typical chemo effects of extreme fatigue, nausea and constant diarrhea right away after the first treatment. I hadn’t heard of all the side effects before starting treatment but tried to track them so my oncologist would at least acknowledge that side effects can vary widely in different people and consider a dose adjustment if needed. Sending you lots of positive energy and support.

Suggest you have the infusion nurse wrap your fingers and toes in ice packs during infusion. This really helps prevent cold sensitivity and peripheral neuropathy

I was on a Capox treatment for 8 cycles. I quit the Oxaliplatin after 4 cycles because the side effects were getting worse. With each treatment, it was taking longer for the side effects to go away. To enjoy any cold drink, I had to take a straw and drink it like a gerbal. And studies have shown that the benefits of 8 cycles vs 4 of Oxaliplatin is pretty low. I have mucinous adenocarcinoma, and this treatment wasn't effective for me and has spread. I worry about the neuropathy in my feet not restoring. Oxaliplatin is a harsh chemo. It bares contemplation whether a different chemo is a better alternative.

Mine was also 6 months - IV and then two weeks of pills, then a week off. I experienced many of the same side effects - day 3 crash, cold sensitivity, nausea, I would lose the ability to walk unassisted, my speech was garbled and my hands didn't function properly during the last 30 minutes of my IV treatments, then I would slowly recover enough to walk on my own over the next 4-5 hours. I lived under an electric blanket and found journalling helpful as well. I ate whatever I could tolerate - ensure and boost protein drinks (room temp) were good.

Hi, thanks for replying. That FOLFOX was no picnic—but we did it! I have residual neuropathy in feet and finger tips—but hoping it will resolve with time. After FOLFOX, a PET scan showed NED (no evidence of disease—yay, knock wood, thank God).
However, now I’m on Xeloda (capecetibine/oral 5-FU) pills. My oncologist said it’s like extra insurance coverage. Instead of 2 weeks on, one week off, my doc has me on 7 days on and 7 days off. Basically, pills every other week. He said some studies have shown that by the second week, drug cumulation potentially may cause more difficult-to-manage side effects. I’m extremely sensitive to ALL meds, so he felt this schedule would be more tolerable for me, and it adds up to the same protocol dosing. (Do not want to cast any doubt on anyone else’s treatment or experience—this is my individual situation.)
Just to be sure: were you on capecetibine (Xeloda/oral 5-FU)? How are you? How did you tolerate the pills? Hope you’re doing well now!