OTC pain relief while on Prednisone?

Posted by superfly999 @superfly999, Oct 17, 2025

Hello! So happy to find this group. Male, age 59, had a cold or COVID (did not test) from Aug. 8 to Aug. 18. Was feeling about 80% better, but then felt the first symptoms of PMR on Aug. 25.

After several referrals, a rheumatologist diagnosed me with PMR a week ago. I suffered for about 6 weeks with extreme shoulder joint pain and extreme tightness/soreness/stiffness in the hamstrings, lower back, upper back, shoulders and neck. My knees joined the party about a week ago. I was basically sofa-bound from late August until mid-October.

Rheumatologist started me on 15mg of Prednisone (taken at 8:00 a.m. when I wake up), which provided immediate relief and has me off the sofa and resuming most activities. I still wake up nightly around 4:00 a.m. with pain in my shoulder serious enough to disrupt my sleep so that I toss and turn until 8:00 a.m. A night of 8 hours of restorative, solid Zzzz's is a distant memory.

Advil and Tylenol seem to have no effect, so I've stopped taking them to spare my liver/kidneys/stomach from processing them while getting little-to-no relief.

I asked my doctor if I should up the Prednisone in the interest of getting a full night of healing sleep, but he said no -- stay at 15mg if I can tolerate the PMR pain, so that's where I am.

That's my story. Glad to have found this group and hope I can contribute and help somebody going through the PMR/Prednisone ordeal.

Oh, my question -- are there any OTC meds that can beat back the early morning pain? If not, has anybody here had success with a mild opioid (e.g., Vicodin) to help with sleep?

Interested in more discussions like this? Go to the Polymyalgia Rheumatica (PMR) Support Group.

I take two 625 mg Tylenol Arthritis which seems to help and I take them again later in the day or before I go to sleep. I have a very fitful sleep, no more than 2-3 hours at a time. Presently on 5 mg prednisone in the AM. Right now I'm having a slight flare so I increased the prednisone a couple mg and will taper back eventually.

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Definitely splitting the Prednisone dose helpful for me.
Alleve twice a day was also effective--- it takes a week to get the full effect. This was the last med I slowly tapered from.

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Try liquid melatonin 1 mg 30-60 minutes before bedtime. That seemed to get me through the whole night (unless the cats woke me up😵‍💫)

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Thank you everyone. You are all my go to Dr's. Bless you all. Xoxjoan

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Profile picture for jfannarbor @jfannarbor

@dlb3 I take Tylenol 1000mg twice a day plus 1 mg prednisone and Kevzara every 14 days for PMR.

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@jfannarbor
Try Tylenol for Arthritis 2 in morning. You may not need more

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You might try Primal Harvest Primal Sleep. Uses nothing but natural herbs and melatonin. It works far better than anything else I've tried. You might be able to sleep well enough to sleep through some pain. Only problem I've found is a dry mouth, but a quick sip of water stops that.

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