Osteoporosis and Melatonin

In two seconds I found this ( I found a lot of sites on both sides of this question):

The relevance of melatonin in partially or wholly restoring optimal function, in a series of disorders related to immune dysfunction, is addressed in this report. This includes the potential relief of both autoimmune diseases and many other ailments involving abnormal immune responses, including the overall diminished effectiveness of body defenses occurring with aging.
https://pubmed.ncbi.nlm.nih.gov/32651969

I clicked on the link but can only read the Summary. How does one get access to read the complete study and results?

I clicked on the link but can only read the Summary. How does one get access to read the complete study and results?

@tsc there are several articles on melatonin and autoimmune diseases that suggest it is beneficial, then I also see sites that say melatonin should be avoided because it causes flares. There also seem to be differences between specific disorders on this.

Here is one pro-melatonin study (2013) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709754/

I have lupus and take it so I wanted to look into it. I will research further!

Here is the most recent analysis I could find of the various studies done in the past few years: "Melatonin effects on bone: Implications for use as a therapy for managing bone loss." The full article is here:
https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12749
I waded through it, and the findings look promising, but need further research. Here was the author's conclusion:
"3 CONCLUSION
Osteoporosis is a significant economic burden comparable or greater than that of a range of chronic noncommunicable diseases (ie, rheumatoid arthritis, asthma, and hypertension).79 The mortality risk related to hip fracture for a 50-year-old woman is 2.8%, which is equivalent to her risk of death from breast cancer and four times higher from endometrial cancer.79 As in women, the mortality rate in men after hip fracture increases with age (even more than women) and is highest in the year after a fracture.79, 84 The mortality rate in men approximately doubled over the first 6 months compared with that in similarly aged women.79, 84

The uniqueness of melatonin as a molecule, which ranges from effects on melatonin (MT2) receptor-mediated osteoblastogenesis through MAPK/Wnt-beta catenin pathways,21 to osteoclast-mediated inhibitory effects through direct151, 173 or indirect (osteoblast-mediated RANKL) melatonin actions,119 to antioxidant properties through mitochondrial melatonin receptors22, 23 or through melatonin's direct actions on mitochondrial membranes,23 induction of antioxidant enzymes, and/or free radical scavenging,18, 26-28, 40, 113, 219-222, 235, 236 makes it an ideal if not essential molecule to promote bone health. The recent discovery of mitochondrial melatonin receptors22, 23 provides fertile ground for future research in understanding their role in melatonin-mediated processes in the body “in general” but especially in bone. These properties of melatonin coupled with its actions on the immune system, circadian entrainment, quality of life, safety profile, and cost284 argues strongly for its use clinically to slow the progression of bone loss in “at risk” populations (eg, aging population, menopausal women, RA, shift workers) or augment bone mass in those with osteopenia, osteoporosis or who have suffered a fragility fracture."

So...what does this mean for us? Well, for most people, it would appear that a small nightly dose of melatonin (3mg) could be helpful, if they have or are trying to prevent osteopenia. Not as clear if one already has osteoporosis, and there is no analysis or study I can find about adding melatonin to supplement other osteoporosis treatment. My bone scores are pretty good for my age (over 70), size and family history. But several family members developed severe osteoporosis in their late 80's. So I will probably add melatonin to my regimen after I run it past my PCP.

Do you already have a diagnosis of osteoporosis? Are you taking medication already?
Sue

Sue - Thank you for your additional research! Yes, I have Osteoporosis (age 67), and continue to look at anything that might help “hold the line”.

I used Forteo for two years and had 12% increase in spine and 5% in hips. Then followed with a Reclast infusion. My Dexa results this year showed some additional slight improvement in Lumbar Spine (now -1.9, improved from -3 in 2019), but the Femoral Neck is stuck at -2.6. Not sure if I’ll do Reclast again this year, or try something else.

Jill

There's evidence that 60 grams of prunes a day helps to maintain bone density, and 100 grams increases it. A study showed that Jarlsberg cheese which contains a variety of K vitamins, helps to maintain bone density.

My Dexa results improved from osteoporosis to osteopenia without medication. However, I'm concerned that my lumbar spine needs to improve, so I'm drinking alkaline water.

Studies about the two foods and water would be listed on Google Scholar.