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Optimal Duration of Hormone Therapy
Not a question, but a discussion item for the Group. This video from PCRI just dropped yesterday and reviews a JAMA study that focuses on best duration of hormone therapy. About 20 minutes long. One really interesting finding is that the longer the duration the higher the likelihood of dying from something other than PC. (As compared to control groups not on ADT ). Probably cardio vascular, osteoporosis caused bone fractures, diabetes…….known side effects. My analysis on the last statement. Anyway, my take on it is that duration of ADT is becoming a more discussed issue and the unintended impacts on a man’s body are starting to be paid more attention to.
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My head is spinning! At a center of excellence along with 40 IMRTs I was prescribed 24 months of ADT (Orgovyx, Zytiga, Prednisone) for stage N1 metastatic hormone sensitive prostate cancer. Due to the annoying side effects I asked my MO if I might change from Zytiga to Nubeqa and reduce these treatment time to 18 months. She advised me she'd rather me continue with the Zytiga and endure the full 24 months. I assume being high risk and the treatment working well makes sense not to mess with success. PSA has been <.05 for many months. I sure am looking forward to getting off the ADT. Opinions on whether her recommendation sounds like a logical one?