Oncotype dx and Mammaprint discordance early stage breast cancer

Posted by coreysmom @coreysmom, Dec 31, 2021

Oncotype Dx 11 score showed low risk, recent Mammaprint reclassified as high risk luminsl b. Has anyone had this situation? I am 4 years out from diagnosis.

Interested in more discussions like this? Go to the Breast Cancer group.

Neither of these test existed when I was diagnosed, but you might check out this discussion or some of the members here and see if they have some ideas about this.
https://connect.mayoclinic.org/discussion/breast-cancer-index/

REPLY

I had grade 3, LVI but low Oncotype of 8 with risk halved by Femara. (Thirty percent of grade 3's have low Oncotype.) Breast Cancer Index at year 5 showed high risk at 5.5% (just over the line and not too different from Oncotype), and low effectiveness of meds. The Prosigna had me at high risk at 10%, 5 years out. You can call each test company to discuss. It's tough that they don't agree.

REPLY

Are you ER+ or ER-, HER+ or HER- ?? Oncotype gives a graded scale of risk broken up into low, intermediate, and high risk categories, whereas MammaPrint is either low or high risk. Oncotype is applicable only to estrogen receptor (ER)–positive tumors; MammaPrint can be used for both ER-positive and ER-negative tumors.Aug 25, 2016

REPLY
@auntieoakley

Neither of these test existed when I was diagnosed, but you might check out this discussion or some of the members here and see if they have some ideas about this.
https://connect.mayoclinic.org/discussion/breast-cancer-index/

Jump to this post

Thank you!

REPLY
@windyshores

I had grade 3, LVI but low Oncotype of 8 with risk halved by Femara. (Thirty percent of grade 3's have low Oncotype.) Breast Cancer Index at year 5 showed high risk at 5.5% (just over the line and not too different from Oncotype), and low effectiveness of meds. The Prosigna had me at high risk at 10%, 5 years out. You can call each test company to discuss. It's tough that they don't agree.

Jump to this post

Thank you! I did contact Mammaprint who explained that they review other factors and that their test should be trusted. I will contact Oncotype Dx and am currently scheduled for BCI test. Thank you again.

REPLY
@auksst

Are you ER+ or ER-, HER+ or HER- ?? Oncotype gives a graded scale of risk broken up into low, intermediate, and high risk categories, whereas MammaPrint is either low or high risk. Oncotype is applicable only to estrogen receptor (ER)–positive tumors; MammaPrint can be used for both ER-positive and ER-negative tumors.Aug 25, 2016

Jump to this post

I am ER+ and HER-. Thank you

REPLY
@coreysmom

Thank you! I did contact Mammaprint who explained that they review other factors and that their test should be trusted. I will contact Oncotype Dx and am currently scheduled for BCI test. Thank you again.

Jump to this post

The BCI people said that Oncotype counts cars on the highway, so to speak, and the BCI looks at how fast they are driving. Or something like that! They all look at different genomic factors. I also got to Prosigna Assay.

REPLY
@windyshores

The BCI people said that Oncotype counts cars on the highway, so to speak, and the BCI looks at how fast they are driving. Or something like that! They all look at different genomic factors. I also got to Prosigna Assay.

Jump to this post

That makes sense. I assume Mammaprint is also looking at how fasr hence being reclassified as high risk.

REPLY
@coreysmom

Thank you! I did contact Mammaprint who explained that they review other factors and that their test should be trusted. I will contact Oncotype Dx and am currently scheduled for BCI test. Thank you again.

Jump to this post

What's a BCI test?

REPLY
In reply to @slapshotmary "What's a BCI test?" + (show)
@slapshotmary

What's a BCI test?

Jump to this post

Th Breast Cancer Index test which tells you whether 5 additional years of endocrine therapy will be useful.

REPLY
Please sign in or register to post a reply.
  Request Appointment