Side effects with omeprazole/Prilosec use

Posted by blueorca @blueorca, May 5, 2018

i am an 18-year user of daily OTC Prilosec. It does a perfect job of controlling my GERD but I am constantly battling side effects of nutritional deficiencies in iron, B-12, magnesium, etc. For example, my hair is extremely thin and loss of energy is a constant problem. I am looking for specific help in knowing which supplements to take for this and in what doses and formats and on what schedule. All the nutritionists I've found locally are not well-versed in Prilosec use. Is there a medical provider out there who specializes in this? And would they be willing to work with me long distance?

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I took Omeprazole for 2 years for GERD and it seemed to be helping a lot. Then day I woke up and my left leg was swollen. After many doctors and loads of tests, I happened to read in a NIH report that Omeprazole sometimes exacerbated arthritis in your joints. Since I have arthritis in my left hip, I went to my Gastro and asked to get off Om. He said he'd never heard of that reaction and RELUCTANTLY put me on Pepcid. Within 48 hours, my leg was back to normal and the Pepcid is handling the GERD just fine.

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Profile picture for fltutu @fltutu

I took Omeprazole for 2 years for GERD and it seemed to be helping a lot. Then day I woke up and my left leg was swollen. After many doctors and loads of tests, I happened to read in a NIH report that Omeprazole sometimes exacerbated arthritis in your joints. Since I have arthritis in my left hip, I went to my Gastro and asked to get off Om. He said he'd never heard of that reaction and RELUCTANTLY put me on Pepcid. Within 48 hours, my leg was back to normal and the Pepcid is handling the GERD just fine.

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Ditto. Proton pump inhibitors like Nexium and Prilosec are
Triggers for a condition called Microscopic colitis - an awful, I’ll do anything to stop it kind of thing.

So
I too transitioned to Pepcid. I had to supplement with an additional one mid afternoon for a few days and then Tums - but now it’s all good.

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I was on Pantoprozole, which is similar, and I weaned myself off. Instead of one pill a day, I took one pill every other day and finally stopped.

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Profile picture for pb50 @pb50

Ditto. Proton pump inhibitors like Nexium and Prilosec are
Triggers for a condition called Microscopic colitis - an awful, I’ll do anything to stop it kind of thing.

So
I too transitioned to Pepcid. I had to supplement with an additional one mid afternoon for a few days and then Tums - but now it’s all good.

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PPIs also create a favorable environment for helicobacter pylori to thrive. ( causes ulcers)

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I am trying to wean off Nexium. Down to every 4 days 20 mg. No issues so far. Wonder if I ever had Gerd. Weird. But it’s caused me to have bleeding stomach
Polyps that are quite large.

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Profile picture for Father of sticky rice @fatherofstickyrice

No, thankfully, I have not had esophageal cancer. My doctor has recommended that I transition from a PPI to an H2 blocker because of the association of long-term use of PPI's with bone density loss (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914803/).

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I have Osteoporosis. I take Osteoporosis meds and bhrt. Because of my acid reflux I was prescribed Omeprazole. When I read that it can inhibit calcium absorbtion I was concerned. Since then I have resumed the ppi and am not going to worry about the calcium issue. At 77 I am refusing to worry about the myriad issues with medication side effects. My life is too short. I

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Profile picture for Father of sticky rice @fatherofstickyrice

10 years ago or so, I had severe symptoms of having food stuck in my esophagus and not being able to swallow or bring food back up. This put me in the hospital a few times until an endoscopy diagnosed me with a schatzki ring. My gastroenterologist nipped it in one or two places and prescribed omeprazole 20 mg once per day. This worked fine for years. My current primary care physician wants me to come off of this proton pump inhibitor (PPI) and use an H2 blocker instead. I agree. I tried about a 10-day transition alternating between the two medications and then went to the H2 blocker (Famotidine) for 3 months with no omeprazole. I had swallowing difficulty symptoms almost every meal. They were mild to severe ( inability to swallow or bring food back up for 20 minutes with a production of fluid [saliva?] which required spitting and some small amounts of food coming up). So, I went back on Omeprazole about a month ago. Now I have obtained a prescription both. I would like to try to wean myself off of the PPI and onto an H2 blocker again. Here is my plan:● Alternate omeprazole 20 mg /day early am with famotidine 20 mg before breakfast and dinner for 14 days. Then alternate with PPI every 3rd day for 14 days. Then alternate with PPI every 4th day for 14 days.Does anyone have any experience with this transition? Any suggestions.

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Hi, I was diagnosed with esophagitis / silent gerd and put on pantoprazole for a few months. When I tried to stop the pantoprazole I had severe heartburn. (I never actually had heartburn before I started the PPI). After ~1 month of torture, I went back on the PPI, but to a half dose. I took half dose for about a month and then alternated that with famotidine until I switched, then started weaning off famotidine. My real question for this group is…is it worse to be on a PPI daily long term or to be on famotidine daily long term or are they equally bad for both osteoporosis and dementia? Does anyone have any insight on this? Thanks

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Profile picture for lamd @lamd

Hi, I was diagnosed with esophagitis / silent gerd and put on pantoprazole for a few months. When I tried to stop the pantoprazole I had severe heartburn. (I never actually had heartburn before I started the PPI). After ~1 month of torture, I went back on the PPI, but to a half dose. I took half dose for about a month and then alternated that with famotidine until I switched, then started weaning off famotidine. My real question for this group is…is it worse to be on a PPI daily long term or to be on famotidine daily long term or are they equally bad for both osteoporosis and dementia? Does anyone have any insight on this? Thanks

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Famotidine (H2 blocker) does not inhibit calcium absorption as Omeprazole (PPI) does.

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Profile picture for lamd @lamd

Hi, I was diagnosed with esophagitis / silent gerd and put on pantoprazole for a few months. When I tried to stop the pantoprazole I had severe heartburn. (I never actually had heartburn before I started the PPI). After ~1 month of torture, I went back on the PPI, but to a half dose. I took half dose for about a month and then alternated that with famotidine until I switched, then started weaning off famotidine. My real question for this group is…is it worse to be on a PPI daily long term or to be on famotidine daily long term or are they equally bad for both osteoporosis and dementia? Does anyone have any insight on this? Thanks

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My gastroenterologist had me go through a protocol to quit Omeprazole. With that ppi, she did not recommend quitting cold turkey.

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Profile picture for mrsbeard26 @mrsbeard26

I’ve been on Prevacid my entire adult life. 27 years. Slowly transitioning off. I’m scared.

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You’ve been on a ppi medicine for 27 years ? I hope you can wean off it successfully. You apparently have GERD or reflux ? That is what I have along with swollen esophagus and I started Prilosec in May though it worries me as to the side effects

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